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Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.<\/jats:p>","DOI":"10.7554\/elife.23661","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T08:00:10Z","timestamp":1488873610000},"source":"Crossref","is-referenced-by-count":121,"title":["Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells"],"prefix":"10.7554","volume":"6","author":[{"given":"Tao","family":"Jiang","sequence":"first","affiliation":[{"name":"Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United States"},{"name":"Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-8215","authenticated-orcid":true,"given":"Katie","family":"Kindt","sequence":"additional","affiliation":[{"name":"Section on Sensory Cell Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-3558","authenticated-orcid":true,"given":"Doris K","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"e09946","DOI":"10.7554\/eLife.09946","article-title":"Coordination of planar cell polarity pathways through Spiny-legs","volume":"4","author":"Ambegaonkar","year":"2015","journal-title":"eLife"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"Arnold","year":"2011","journal-title":"Cell Stem Cell"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.celrep.2014.06.009","article-title":"Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila","volume":"8","author":"Ayukawa","year":"2014","journal-title":"Cell Reports"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"13869","DOI":"10.1073\/pnas.1222341110","article-title":"Auditory ganglion source of sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells","volume":"110","author":"Bok","year":"2013","journal-title":"PNAS"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"E3129","DOI":"10.1073\/pnas.1404988111","article-title":"A dual role for planar cell polarity genes in ciliated cells","volume":"111","author":"Boutin","year":"2014","journal-title":"PNAS"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/bies.201600154","article-title":"Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity","volume":"38","author":"Carvajal-Gonzalez","year":"2016","journal-title":"BioEssays"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"11135","DOI":"10.1038\/ncomms11135","article-title":"Positioning of centrioles is a conserved readout of frizzled planar cell polarity signalling","volume":"7","author":"Carvajal-Gonzalez","year":"2016","journal-title":"Nature Communications"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/dneu.20962","article-title":"Building the posterior lateral line system in zebrafish","volume":"72","author":"Chitnis","year":"2012","journal-title":"Developmental Neurobiology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/neu.20171","article-title":"Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear","volume":"64","author":"Dabdoub","year":"2005","journal-title":"Journal of Neurobiology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1523\/JNEUROSCI.5151-06.2007","article-title":"Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear","volume":"27","author":"Deans","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1152\/jn.00746.2003","article-title":"Comparative morphology of rodent vestibular periphery. 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