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Here, we test how neuronal selectivity for visual features is transformed into decision-related signals in posterior parietal cortex (area LIP). Monkeys performed a visual matching task that required them to detect target stimuli composed of conjunctions of color and motion-direction. Neuronal recordings from area LIP revealed two main findings. First, the sequential processing of visual features and the selection of target-stimuli suggest that LIP is involved in transforming sensory information into decision-related signals. Second, the patterns of color and motion selectivity and their impact on decision-related encoding suggest that LIP plays a role in detecting target stimuli by comparing bottom-up sensory inputs (what the monkeys were looking at) and top-down cognitive encoding inputs (what the monkeys were looking for).<\/jats:p>","DOI":"10.7554\/elife.23743","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T08:00:22Z","timestamp":1492502422000},"source":"Crossref","is-referenced-by-count":20,"title":["Sequential sensory and decision processing in posterior parietal cortex"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-1280","authenticated-orcid":true,"given":"Guilhem","family":"Ibos","sequence":"first","affiliation":[{"name":"Department of Neurobiology, The University of Chicago, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5981","authenticated-orcid":true,"given":"David J","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, The University of Chicago, Chicago, United States"},{"name":"Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.neuro.25.112701.142922","article-title":"Intentional maps in posterior parietal cortex","volume":"25","author":"Andersen","year":"2002","journal-title":"Annual Review of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1093\/cercor\/bhr035","article-title":"A pure salience response in posterior parietal cortex","volume":"21","author":"Arcizet","year":"2011","journal-title":"Cerebral Cortex"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1152\/jn.00527.2012","article-title":"High-performance execution of psychophysical tasks with complex visual stimuli in MATLAB","volume":"109","author":"Asaad","year":"2013","journal-title":"Journal of Neurophysiology"},{"key":"bib4","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1152\/jn.1991.66.3.1095","article-title":"Saccade-related activity in the lateral intraparietal area. 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