{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:47:45Z","timestamp":1790387265428,"version":"4.1.0"},"reference-count":66,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yousef Jameel Foundation"},{"DOI":"10.13039\/501100003343","name":"Cambridge Commonwealth, European and International Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L021706\/1"],"award-info":[{"award-number":["BB\/L021706\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["MCSA fellowship 660516"],"award-info":[{"award-number":["MCSA fellowship 660516"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["08136"],"award-info":[{"award-number":["08136"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["MCSA fellowship 236777"],"award-info":[{"award-number":["MCSA fellowship 236777"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["Singapore A*STAR Scholarship BM\/RES\/07\/005"],"award-info":[{"award-number":["Singapore A*STAR Scholarship BM\/RES\/07\/005"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["MCSA fellowship 220851"],"award-info":[{"award-number":["MCSA fellowship 220851"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["MCSA fellowship 220874"],"award-info":[{"award-number":["MCSA fellowship 220874"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","award":["Studentship 861-792"],"award-info":[{"award-number":["Studentship 861-792"]}],"id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["Pakistan HEC Scholarship"],"award-info":[{"award-number":["Pakistan HEC Scholarship"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Hereditary Spastic Paraplegia Support Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). We show that Drosophila axons have a dynamic axonal ER network, which these proteins help to model. Loss of HSP hairpin proteins causes ER sheet expansion, partial loss of ER from distal motor axons, and occasional discontinuities in axonal ER. Ultrastructural analysis reveals an extensive ER network in axons, which shows larger and fewer tubules in larvae that lack reticulon and REEP proteins, consistent with loss of membrane curvature. Therefore HSP hairpin-containing proteins are required for shaping and continuity of axonal ER, thus suggesting roles for ER modeling in axon maintenance and function.<\/jats:p>","DOI":"10.7554\/elife.23882","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T08:00:09Z","timestamp":1500969609000},"source":"Crossref","is-referenced-by-count":80,"title":["Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins"],"prefix":"10.7554","volume":"6","author":[{"given":"Belgin","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7528-4034","authenticated-orcid":true,"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stofanko","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh C","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Han","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Roost","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Zaessinger","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Blard","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex L","family":"Patto","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anood","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Baena","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Connecticut Health Center, Farmington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Connecticut Health Center, Farmington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-2078","authenticated-orcid":true,"given":"Cahir J","family":"O'Kane","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev-biochem-052809-155121","article-title":"Mechanisms of membrane curvature sensing","volume":"80","author":"Antonny","year":"2011","journal-title":"Annual Review of Biochemistry"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1172\/JCI65665","article-title":"A spastic paraplegia mouse model reveals REEP1-dependent ER shaping","volume":"123","author":"Beetz","year":"2013","journal-title":"Journal of Clinical Investigation"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ajhg.2012.05.007","article-title":"Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V","volume":"91","author":"Beetz","year":"2012","journal-title":"The American Journal of Human Genetics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/emboj.2011.494","article-title":"Axonal transcription factors signal retrogradely in lesioned peripheral nerve","volume":"31","author":"Ben-Yaakov","year":"2012","journal-title":"The EMBO Journal"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signaling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nrn2990","article-title":"Hereditary spastic paraplegias: membrane traffic and the motor pathway","volume":"12","author":"Blackstone","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-neuro-062111-150400","article-title":"Cellular pathways of hereditary spastic paraplegia","volume":"35","author":"Blackstone","year":"2012","journal-title":"Annual Review of Neuroscience"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ng2049","article-title":"Using FlyAtlas to identify better Drosophila Melanogaster models of human disease","volume":"39","author":"Chintapalli","year":"2007","journal-title":"Nature Genetics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cell.2013.10.004","article-title":"Injury-induced HDAC5 nuclear export is essential for axon regeneration","volume":"155","author":"Cho","year":"2013","journal-title":"Cell"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","author":"Dietzl","year":"2007","journal-title":"Nature"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ajhg.2013.12.005","article-title":"Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia","volume":"94","author":"Esteves","year":"2014","journal-title":"The American Journal of Human Genetics"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"ddw139","DOI":"10.1093\/hmg\/ddw139","article-title":"ER-shaping proteins are required for ER and mitochondrial network organization in motor neurons","volume":"25","author":"Fowler","year":"2016","journal-title":"Human Molecular Genetics"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1523\/JNEUROSCI.5464-09.2010","article-title":"Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase","volume":"30","author":"Ghosh-Roy","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/15472","article-title":"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia","volume":"23","author":"Hazan","year":"1999","journal-title":"Nature Genetics"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/oxfordjournals.jmicro.a050013","article-title":"Membrane proteins of the endoplasmic reticulum induce high-curvature tubules","volume":"319","author":"Hu","year":"2008","journal-title":"Science"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/humu.22378","article-title":"Hereditary spastic paraplegia type 43 (SPG43) is caused by mutation in C19orf12","volume":"34","author":"Landour\u00e9","year":"2013","journal-title":"Human Mutation"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"bib19","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1523\/JNEUROSCI.05-12-03135.1985","article-title":"The neuronal endomembrane system. III. The origins of the axoplasmic reticulum and discrete axonal cisternae at the axon hillock","volume":"5","author":"Lindsey","year":"1985","journal-title":"Journal of Neuroscience"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1242\/dev.116616","article-title":"Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog vein","volume":"142","author":"Matzat","year":"2015","journal-title":"Development"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1172\/JCI60560","article-title":"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12","volume":"122","author":"Montenegro","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"aaf3928","DOI":"10.1126\/science.aaf3928","article-title":"Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER","volume":"354","author":"Nixon-Abell","year":"2016","journal-title":"Science"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1126\/science.1247363","article-title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders","volume":"343","author":"Novarino","year":"2014","journal-title":"Science"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1093\/hmg\/dds167","article-title":"Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons","volume":"21","author":"O'Sullivan","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, Spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"Journal of Clinical Investigation"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0896-6273(01)00485-8","article-title":"Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix","volume":"32","author":"Parnas","year":"2001","journal-title":"Neuron"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuron.2012.05.033","article-title":"Subcellular knockout of importin \u03b21 perturbs axonal retrograde signaling","volume":"75","author":"Perry","year":"2012","journal-title":"Neuron"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrm.2015.8","article-title":"Structure and function of ER membrane contact sites with other organelles","volume":"17","author":"Phillips","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nmeth.1199","article-title":"BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals","volume":"5","author":"Poser","year":"2008","journal-title":"Nature Methods"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1091\/mbc.E16-05-0287","article-title":"Spastin, Atlastin, and ER relocalization are involved in axon but not dendrite regeneration","volume":"27","author":"Rao","year":"2016","journal-title":"Molecular Biology of the Cell"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/genetics\/118.3.461","article-title":"A stable genomic source of P element transposase in Drosophila Melanogaster","volume":"118","author":"Robertson","year":"1988","journal-title":"Genetics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nrn3168","article-title":"Understanding calcium waves and sparks in central neurons","volume":"13","author":"Ross","year":"2012","journal-title":"Nature Reviews Neuroscience"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/sj.emboj.7601477","article-title":"Unfolded protein response in a Drosophila model for retinal degeneration","volume":"26","author":"Ryoo","year":"2007","journal-title":"The EMBO Journal"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1242\/jcs.03407","article-title":"Rtnl1 is enriched in a specialized germline ER that associates with ribonucleoprotein granule components","volume":"120","author":"R\u00f6per","year":"2007","journal-title":"Journal of Cell Science"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nature Methods"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev.cellbio.042308.113324","article-title":"Mechanisms shaping the membranes of cellular organelles","volume":"25","author":"Shibata","year":"2009","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.cell.2010.11.007","article-title":"Mechanisms determining the morphology of the peripheral ER","volume":"143","author":"Shibata","year":"2010","journal-title":"Cell"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.cell.2006.07.019","article-title":"Rough sheets and smooth tubules","volume":"126","author":"Shibata","year":"2006","journal-title":"Cell"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"18892","DOI":"10.1074\/jbc.M800986200","article-title":"The reticulon and DP1\/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum","volume":"283","author":"Shibata","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cell.2016.05.029","article-title":"Dynamic Axonal translation in developing and mature visual circuits","volume":"166","author":"Shigeoka","year":"2016","journal-title":"Cell"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00215114","article-title":"Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions","volume":"175","author":"Stewart","year":"1994","journal-title":"Journal of Comparative Physiology A"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1523\/JNEUROSCI.4367-07.2008","article-title":"Organization and function of the blood-brain barrier in Drosophila","volume":"28","author":"Stork","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1242\/jcs.184929","article-title":"The effects of ER morphology on synaptic structure and function in Drosophila Melanogaster","volume":"129","author":"Summerville","year":"2016","journal-title":"Journal of Cell Science"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Molecular Biology and Evolution"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nprot.2011.439","article-title":"High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy","volume":"7","author":"Tapia","year":"2012","journal-title":"Nature Protocols"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cell.2013.06.031","article-title":"Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs","volume":"154","author":"Terasaki","year":"2013","journal-title":"Cell"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"7510","DOI":"10.1073\/pnas.91.16.7510","article-title":"Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons","volume":"91","author":"Terasaki","year":"1994","journal-title":"PNAS"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1242\/jcs.120493","article-title":"The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage","volume":"126","author":"Thiel","year":"2013","journal-title":"Journal of Cell Science"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1016\/j.bbamcr.2013.04.010","article-title":"The complexity of sphingolipid biosynthesis in the endoplasmic reticulum","volume":"1833","author":"Tidhar","year":"2013","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/oxfordjournals.jmicro.a050013","article-title":"Three-dimensional distribution of smooth endoplasmic reticulum in myelinated axons","volume":"25","author":"Tsukita","year":"1976","journal-title":"Journal of Electron Microscopy"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nature22369","article-title":"Applying systems-level spectral imaging and analysis to reveal the organelle interactome","volume":"546","author":"Valm","year":"2017","journal-title":"Nature"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid synthesis and transport in mammalian cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nmeth.1331","article-title":"Versatile P[acman] BAC libraries for transgenesis studies in Drosophila Melanogaster","volume":"6","author":"Venken","year":"2009","journal-title":"Nature Methods"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"7179","DOI":"10.1523\/JNEUROSCI.4784-13.2014","article-title":"Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction","volume":"34","author":"Villegas","year":"2014","journal-title":"Journal of Neuroscience"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.cell.2005.11.047","article-title":"A class of membrane proteins shaping the tubular endoplasmic reticulum","volume":"124","author":"Voeltz","year":"2006","journal-title":"Cell"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1007\/s00018-006-6142-3","article-title":"The Drosophila reticulon, Rtnl-1, has multiple differentially expressed isoforms that are associated with a sub-compartment of the endoplasmic reticulum","volume":"63","author":"Wakefield","year":"2006","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cell.2008.11.046","article-title":"The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility","volume":"136","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"E4859","DOI":"10.1073\/pnas.1701078114","article-title":"Contacts between the endoplasmic reticulum and other membranes in neurons","volume":"114","author":"Wu","year":"2017","journal-title":"PNAS"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1083\/jcb.201006039","article-title":"Protein turnover of the Wallenda\/DLK kinase regulates a retrograde response to axonal injury","volume":"191","author":"Xiong","year":"2010","journal-title":"The Journal of Cell Biology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/BJ20131186","article-title":"Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion","volume":"458","author":"Yamamoto","year":"2014","journal-title":"Biochemical Journal"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1093\/hmg\/ddp332","article-title":"Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp\/BMP production and visual wiring in the brain","volume":"18","author":"Zhang","year":"2009","journal-title":"Human Molecular Genetics"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/ng758","article-title":"Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia","volume":"29","author":"Zhao","year":"2001","journal-title":"Nature Genetics"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1126\/science.8310297","article-title":"Paralysis and early death in cysteine string protein mutants of Drosophila","volume":"263","author":"Zinsmaier","year":"1994","journal-title":"Science"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"15464","DOI":"10.1523\/JNEUROSCI.1800-10.2010","article-title":"Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs","volume":"30","author":"Zivraj","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1086\/505361","article-title":"Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31","volume":"79","author":"Z\u00fcchner","year":"2006","journal-title":"The American Journal of Human Genetics"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/23882\/elife-23882-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/23882\/elife-23882-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/23882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:51:03Z","timestamp":1697057463000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/23882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":66,"alternative-id":["10.7554\/eLife.23882"],"URL":"https:\/\/doi.org\/10.7554\/elife.23882","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17863\/CAM.12206","asserted-by":"subject"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/069005","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.23882.032","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.23882.031","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]},"article-number":"e23882"}}