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In addition,\n                    <jats:italic>ARID1B<\/jats:italic>\n                    is the most common cause of Coffin-Siris syndrome, a developmental delay syndrome characterized by some of the above abnormalities (Santen et al., 2012; Tsurusaki et al., 2012; Wieczorek et al., 2013). We generated\n                    <jats:italic>Arid1b<\/jats:italic>\n                    heterozygous mice, which showed social behavior impairment, altered vocalization, anxiety-like behavior, neuroanatomical abnormalities, and growth impairment. In the brain,\n                    <jats:italic>Arid1b<\/jats:italic>\n                    haploinsufficiency resulted in changes in the expression of SWI\/SNF-regulated genes implicated in neuropsychiatric disorders. A focus on reversible mechanisms identified Insulin-like growth factor (IGF1) deficiency with inadequate compensation by Growth hormone-releasing hormone (GHRH) and Growth hormone (GH), underappreciated findings in\n                    <jats:italic>ARID1B<\/jats:italic>\n                    patients. Therapeutically, GH supplementation was able to correct growth retardation and muscle weakness. This model functionally validates the involvement of\n                    <jats:italic>ARID1B<\/jats:italic>\n                    in human disorders, and allows mechanistic dissection of neurodevelopmental diseases linked to chromatin-remodeling.\n                  <\/jats:p>","DOI":"10.7554\/elife.25730","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T20:00:13Z","timestamp":1499716813000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.25730","source":"Crossref","is-referenced-by-count":102,"title":["Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3750","authenticated-orcid":true,"given":"Cemre","family":"Celen","sequence":"first","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Chieh","family":"Chuang","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United 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States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"Chung","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liem H","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Nassour","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Budhipramono","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxu","family":"Sun","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levinus A","family":"Bok","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, M\u00e1xima Medical Center, Veldhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriel","family":"McEntagart","sequence":"additional","affiliation":[{"name":"Medical Genetics, St George's University Hospitals, NHS Foundation Trust, United Kingdom Caroline Brain, Endocrinology, Great Ormond Street Hospital for Children, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien F","family":"Gevers","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari 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