{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:12:15Z","timestamp":1792678335789,"version":"4.5.0"},"reference-count":61,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 216-2013"],"award-info":[{"award-number":["ALTF 216-2013"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006516","name":"Bertil H\u00e5llstens Forskningsstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006516","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u00c5ke Wiberg Stiftelse"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.<\/jats:p>","DOI":"10.7554\/elife.25902","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T08:00:15Z","timestamp":1492416015000},"source":"Crossref","is-referenced-by-count":62,"title":["Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-9769","authenticated-orcid":true,"given":"Marketa","family":"Kaucka","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Center for Brain Research, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Zikmund","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marketa","family":"Tesarova","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gyllborg","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hellander","sequence":"additional","affiliation":[{"name":"Department of Information Technology, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Jaros","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical Faculty, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bara","family":"Szarowska","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip T","family":"Newton","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav","family":"Dyachuk","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sofie","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Mishina","sequence":"additional","affiliation":[{"name":"Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Currie","sequence":"additional","affiliation":[{"name":"Center for Regenerative Therapies, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly M","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center for Regenerative Therapies, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alek","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-4003","authenticated-orcid":true,"given":"Hjalmar","family":"Brismar","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Royal Institute of Technology, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Southam","sequence":"additional","affiliation":[{"name":"John Innes Centre, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-8767","authenticated-orcid":true,"given":"Enrico","family":"Coen","sequence":"additional","affiliation":[{"name":"John Innes Centre, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S","family":"Weinstein","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ales","family":"Hampl","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical Faculty, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Arenas","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-5850","authenticated-orcid":true,"given":"Andrei S","family":"Chagin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-0356","authenticated-orcid":true,"given":"Igor","family":"Adameyko","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Center for Brain Research, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1210\/endo.143.5.8776","article-title":"The role of the resting zone in growth plate chondrogenesis","volume":"143","author":"Abad","year":"2002","journal-title":"Endocrinology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.prrv.2013.02.009","article-title":"Respiratory difficulties and breathing disorders in achondroplasia","volume":"14","author":"Afsharpaiman","year":"2013","journal-title":"Paediatric Respiratory Reviews"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"10525","DOI":"10.1073\/pnas.1217391110","article-title":"Anisotropic growth shapes intestinal tissues during embryogenesis","volume":"110","author":"Ben Amar","year":"2013","journal-title":"PNAS"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1038\/emboj.2013.225","article-title":"The force and effect of cell proliferation","volume":"32","author":"Campinho","year":"2013","journal-title":"The EMBO Journal"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1038\/ncomms4673","article-title":"G-protein stimulatory subunit alpha and gq\/11\u03b1 G-proteins are both required to maintain quiescent stem-like chondrocytes","volume":"5","author":"Chagin","year":"2014","journal-title":"Nature Communications"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/dvdy.23726","article-title":"Signaling by SHH rescues facial defects following blockade in the brain","volume":"241","author":"Chong","year":"2012","journal-title":"Developmental Dynamics"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1203\/01.pdr.0000214966.60416.1b","article-title":"Impaired growth plate chondrogenesis in children with chronic illnesses","volume":"59","author":"De Luca","year":"2006","journal-title":"Pediatric Research"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"995","DOI":"10.14670\/HH-21.995","article-title":"Adult stem and transit-amplifying cell location","volume":"21","author":"D\u00edaz-Flores","year":"2006","journal-title":"Histology and Histopathology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.1242\/dev.023309","article-title":"The genesis of cartilage size and shape during development and evolution","volume":"135","author":"Eames","year":"2008","journal-title":"Development"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of cre recombinase activity by mutated estrogen receptor ligand-binding domains","volume":"237","author":"Feil","year":"1997","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.pbiomolbio.2013.09.003","article-title":"Implementing vertex dynamics models of cell populations in biology within a consistent computational framework","volume":"113","author":"Fletcher","year":"2013","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ydbio.2007.09.016","article-title":"Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development","volume":"312","author":"Foppiano","year":"2007","journal-title":"Developmental Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1359\/jbmr.070420","article-title":"Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth","volume":"22","author":"Ford-Hutchinson","year":"2007","journal-title":"Journal of Bone and Mineral Research"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1038\/ncomms4700","article-title":"Shared developmental programme strongly constrains beak shape diversity in songbirds","volume":"5","author":"Fritz","year":"2014","journal-title":"Nature Communications"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/dvg.20201","article-title":"Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2","volume":"44","author":"Fukuda","year":"2006","journal-title":"Genesis"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.devcel.2011.01.001","article-title":"Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2","volume":"20","author":"Gao","year":"2011","journal-title":"Developmental Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/jcb.20652","article-title":"The control of chondrogenesis","volume":"97","author":"Goldring","year":"2006","journal-title":"Journal of Cellular Biochemistry"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1103\/PhysRevLett.69.2013","article-title":"Simulation of biological cell sorting using a two-dimensional extended Potts model","volume":"69","author":"Graner","year":"1992","journal-title":"Physical Review Letters"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"e1000537","DOI":"10.1371\/journal.pbio.1000537","article-title":"Genetic control of organ shape and tissue polarity","volume":"8","author":"Green","year":"2010","journal-title":"PLoS Biology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"e1000308","DOI":"10.1371\/journal.pgen.1000308","article-title":"Shaping skeletal growth by modular regulatory elements in the Bmp5 gene","volume":"4","author":"Guenther","year":"2008","journal-title":"PLoS Genetics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1242\/dev.073064","article-title":"Temporal control of neural crest lineage generation by wnt\/\u03b2-catenin signaling","volume":"139","author":"Hari","year":"2012","journal-title":"Development"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s004290100178","article-title":"The development of articular cartilage: evidence for an appositional growth mechanism","volume":"203","author":"Hayes","year":"2001","journal-title":"Anatomy and Embryology"},{"key":"bib23","article-title":"multicell","volume-title":"Github","author":"Hellander","year":"2015","unstructured":"Hellander A. 2015. multicell. Github. e7edeef. https:\/\/github.com\/ahellander\/multicell."},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24284","article-title":"Signals from the brain induce variation in avian facial shape","author":"Hu","year":"2015","journal-title":"Developmental Dynamics : An Official Publication of the American Association of Anatomists"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1084\/jem.20132409","article-title":"Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells","volume":"211","author":"Jarjour","year":"2014","journal-title":"The Journal of Experimental Medicine"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"e1600060","DOI":"10.1126\/sciadv.1600060","article-title":"Analysis of neural crest-derived clones reveals novel aspects of facial development","volume":"2","author":"Kaucka","year":"2016","journal-title":"Science Advances"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"e1002071","DOI":"10.1371\/journal.pcbi.1002071","article-title":"Generation of diverse biological forms through combinatorial interactions between tissue polarity and growth","volume":"7","author":"Kennaway","year":"2011","journal-title":"PLoS Computational Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/dgd.12002","article-title":"Cartilage on the move: cartilage lineage tracing during tadpole metamorphosis","volume":"54","author":"Kerney","year":"2012","journal-title":"Development, Growth & Differentiation"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1002\/ar.a.20402","article-title":"Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base","volume":"288","author":"Kettunen","year":"2006","journal-title":"The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"e26393","DOI":"10.1371\/journal.pone.0026393","article-title":"Presence of cartilage stem\/progenitor cells in adult mice auricular perichondrium","volume":"6","author":"Kobayashi","year":"2011","journal-title":"PLoS One"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.1214678","article-title":"Generation of leaf shape through early patterns of growth and tissue polarity","volume":"335","author":"Kuchen","year":"2012","journal-title":"Science"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1172\/JCI58200","article-title":"Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury","volume":"121","author":"Laranjeira","year":"2011","journal-title":"Journal of Clinical Investigation"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1002\/dvdy.22752","article-title":"The Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses","volume":"240","author":"Laurita","year":"2011","journal-title":"Developmental Dynamics"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S1044-7431(03)00029-0","article-title":"Tamoxifen-inducible glia-specific cre mice for somatic mutagenesis in oligodendrocytes and schwann cells","volume":"22","author":"Leone","year":"2003","journal-title":"Molecular and Cellular Neuroscience"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1096\/fj.201600918R","article-title":"Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice","volume":"31","author":"Li","year":"2017","journal-title":"The FASEB Journal"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/(SICI)1098-2353(1999)12:5<315::AID-CA2>3.0.CO;2-2","article-title":"Spatial and temporal distribution of cellular proliferation in the cranial base of normal and midfacially retrusive mice","volume":"12","author":"Ma","year":"1999","journal-title":"Clinical Anatomy"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","article-title":"Endochondral ossification: how cartilage is converted into bone in the developing skeleton","volume":"40","author":"Mackie","year":"2008","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Developmental Cell"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"16222","DOI":"10.1073\/pnas.1206205109","article-title":"Closely related bird species demonstrate flexibility between beak morphology and underlying developmental programs","volume":"109","author":"Mallarino","year":"2012","journal-title":"PNAS"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ydbio.2008.07.016","article-title":"Development and tissue origins of the mammalian cranial base","volume":"322","author":"McBratney-Owen","year":"2008","journal-title":"Developmental Biology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/154405910808700309","article-title":"Wnt\/beta-catenin signaling regulates cranial base development and growth","volume":"87","author":"Nagayama","year":"2008","journal-title":"Journal of Dental Research"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1002\/dvdy.20892","article-title":"Kinetics of tamoxifen-regulated cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton","volume":"235","author":"Nakamura","year":"2006","journal-title":"Developmental Dynamics"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000088791","article-title":"Endocrine regulation of the growth plate","volume":"64","author":"Nilsson","year":"2005","journal-title":"Hormone Research in Paediatrics"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"051907","DOI":"10.1103\/PhysRevE.79.051907","article-title":"Comparing the growth kinetics of cell populations in two and three dimensions","volume":"79","author":"Radszuweit","year":"2009","journal-title":"Physical Review E"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1242\/dev.095760","article-title":"Cell fate respecification and cell division orientation drive intercalary regeneration in Drosophila wing discs","volume":"140","author":"Repiso","year":"2013","journal-title":"Development"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1359\/JBMR.041210","article-title":"Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation","volume":"20","author":"Sakamoto","year":"2005","journal-title":"Journal of Bone and Mineral Research"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"20130726","DOI":"10.1098\/rsif.2013.0726","article-title":"Glassy dynamics in three-dimensional embryonic tissues","volume":"10","author":"Sch\u00f6tz","year":"2013","journal-title":"Journal of the Royal Society Interface"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.1038\/ncomms5800","article-title":"Morphological and population genomic evidence that human faces have evolved to signal individual identity","volume":"5","author":"Sheehan","year":"2014","journal-title":"Nature Communications"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","article-title":"Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells","volume":"143","author":"Snippert","year":"2010","journal-title":"Cell"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"R758","DOI":"10.1016\/j.cub.2005.08.053","article-title":"Organ shape: controlling oriented cell division","volume":"15","author":"Strutt","year":"2005","journal-title":"Current Biology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"C03006","DOI":"10.1088\/1748-0221\/11\/03\/C03006","article-title":"Use of micro computed-tomography and 3D printing for reverse engineering of mouse embryo nasal capsule","volume":"11","author":"Tesa\u0159ov\u00e1","year":"2016","journal-title":"Journal of Instrumentation"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1002\/dvdy.23831","article-title":"The origin of the stapes and relationship to the otic capsule and oval window","volume":"241","author":"Thompson","year":"2012","journal-title":"Developmental Dynamics"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s40571-015-0082-3","article-title":"Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results","volume":"2","author":"Van Liedekerke","year":"2015","journal-title":"Computational Particle Mechanics"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1073\/pnas.96.8.4455","article-title":"A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3","volume":"96","author":"Wang","year":"1999","journal-title":"PNAS"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/ar.a.20385","article-title":"Endochondral ossification of the mouse nasal septum","volume":"288","author":"Wealthall","year":"2006","journal-title":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology"},{"key":"bib59","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1242\/dev.126.6.1211","article-title":"A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo","volume":"126","author":"Yamaguchi","year":"1999","journal-title":"Development"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ydbio.2006.07.028","article-title":"Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function","volume":"299","author":"Young","year":"2006","journal-title":"Developmental Biology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1242\/dev.090845","article-title":"Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord","volume":"140","author":"Yu","year":"2013","journal-title":"Development"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/25902\/elife-25902-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/25902\/elife-25902-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/25902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:53:58Z","timestamp":1697057638000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/25902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":61,"alternative-id":["10.7554\/eLife.25902"],"URL":"https:\/\/doi.org\/10.7554\/elife.25902","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.25902.028","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.25902.027","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]},"article-number":"e25902"}}