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SUN5 is a new member of the SUN family, with little knowledge regarding its function. Here, we generated Sun5\u2212\/\u2212 mice and found that male mice were infertile. Most Sun5-null spermatozoa displayed a globozoospermia-like phenotype but they were actually acephalic spermatozoa. Additional studies revealed that SUN5 was located in the neck of the spermatozoa, anchoring sperm head to the tail, and without functional SUN5 the sperm head to tail coupling apparatus was detached from nucleus during spermatid elongation. Finally, we found that healthy heterozygous offspring could be obtained via intracytoplasmic injection of Sun5-mutated sperm heads for both male mice and patients. Our studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility.<\/jats:p>","DOI":"10.7554\/elife.28199","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T08:00:25Z","timestamp":1506326425000},"source":"Crossref","is-referenced-by-count":136,"title":["Essential role for SUN5 in anchoring sperm head to the tail"],"prefix":"10.7554","volume":"6","author":[{"given":"Yongliang","family":"Shang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, The 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