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Mathers Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH112689"],"award-info":[{"award-number":["R01 MH112689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion genes expressed in three interacting neurons in the mating circuits of the adult male. Two interacting pairs of cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsynaptic target interneuron AVG: BAM-2\/neurexin-related in HOA binds to CASY-1\/calsyntenin in AVG; SAX-7\/L1CAM in sensory neuron PHC binds to RIG-6\/contactin in AVG. A third, basal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two. The features of this multiplexed mechanism help to explain how complex connectivity is encoded and robustly established during nervous system development.<\/jats:p>","DOI":"10.7554\/elife.29257","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T08:00:16Z","timestamp":1505289616000},"source":"Crossref","is-referenced-by-count":49,"title":["Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-7406","authenticated-orcid":true,"given":"Byunghyuk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Genetics, Albert Einstein College of Medicine, Bronx, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W","family":"Emmons","sequence":"additional","affiliation":[{"name":"Department of Genetics, Albert Einstein College of Medicine, Bronx, United States"},{"name":"Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neuron.2013.10.060","article-title":"Neuronal Ig\/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord","volume":"81","author":"Ashrafi","year":"2014","journal-title":"Neuron"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1126\/science.1066642","article-title":"Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization","volume":"295","author":"Aurelio","year":"2002","journal-title":"Science"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1126\/science.282.5396.2028","article-title":"Neurobiology of the Caenorhabditis elegans genome","volume":"282","author":"Bargmann","year":"1998","journal-title":"Science"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/oxfordjournals.bmb.a071019","article-title":"The genetics of behaviour","volume":"29","author":"Brenner","year":"1973","journal-title":"British Medical Bulletin"},{"key":"bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/j.cell.2015.11.022","article-title":"Control of synaptic connectivity by a network of Drosophila IgSF cell surface proteins","volume":"163","author":"Carrillo","year":"2015","journal-title":"Cell"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1126\/science.1089163","article-title":"A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans","volume":"302","author":"Colavita","year":"2003","journal-title":"Science"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.1143762","article-title":"Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans","volume":"318","author":"Col\u00f3n-Ramos","year":"2007","journal-title":"Science"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn.2015.3","article-title":"Specification of synaptic connectivity by cell surface interactions","volume":"17","author":"de Wit","year":"2016","journal-title":"Nature Reviews. 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