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To elucidate the central encoding of this visceral demand, multisite recordings were made within a putative pontine-cortical micturition circuit from the pontine micturition center (PMC), locus coeruleus (LC) and medial prefrontal cortex (mPFC) during cystometry in unanesthetized rats. PMC neurons had homogeneous firing patterns, characterized by tonic activity and phasic bursts that were temporally associated with distinct phases of the micturition cycle. LC and cortical activation became synchronized 20-30 s prior to micturition. During this pre-micturition interval, a theta oscillation developed in the LC, the mPFC desynchronized and LC-mPFC coherence increased in the theta frequency range. The temporal offset between the shift in LC-mPFC network activity and micturition may allow time to disengage from ongoing behaviors unrelated to micturition and initiate specific voiding behaviors so that micturition occurs in environmentally and socially appropriate conditions.<\/jats:p>","DOI":"10.7554\/elife.29917","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T08:02:14Z","timestamp":1511337734000},"source":"Crossref","is-referenced-by-count":30,"title":["Brainstem network dynamics underlying the encoding of bladder information"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-2623","authenticated-orcid":true,"given":"Anitha","family":"Manohar","sequence":"first","affiliation":[{"name":"The Children\u2019s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre 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