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Our extensive omics analyses provide a high-quality resource of altered gene expression patterns under severe OXPHOS deficiency comparing several mouse models, that will deepen our understanding, open avenues for research and provide an important reference for diagnosis and treatment.<\/jats:p>","DOI":"10.7554\/elife.30952","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T19:00:14Z","timestamp":1510599614000},"source":"Crossref","is-referenced-by-count":261,"title":["Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0859","authenticated-orcid":true,"given":"Inge","family":"K\u00fchl","sequence":"first","affiliation":[{"name":"Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany"},{"name":"Department of Cell Biology, Institute of Integrative Biology of the Cell (I2BC) UMR9198, CEA, CNRS, Univ. 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