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However, the outcomes of brain stimulation are shaped by behavioral states and endogenous fluctuations in brain activity. To better understand how this intrinsic oscillatory activity controls the susceptibility of the brain to stimulation, we analyzed a computational model of the thalamo-cortical system in two distinct states (rest and task-engaged) to identify the mechanisms by which endogenous alpha oscillations (8Hz\u201312Hz) are modulated by periodic stimulation. Our analysis shows that the different responses to stimulation observed experimentally in these brain states can be explained by a passage through a bifurcation combined with stochastic resonance \u2014 a mechanism by which irregular fluctuations amplify the response of a nonlinear system to weak periodic signals. Indeed, our findings suggest that modulation of brain oscillations is best achieved in states of low endogenous rhythmic activity, and that irregular state-dependent fluctuations in thalamic inputs shape the susceptibility of cortical population to periodic stimulation.<\/jats:p>","DOI":"10.7554\/elife.32054","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T08:03:07Z","timestamp":1514361787000},"source":"Crossref","is-referenced-by-count":55,"title":["Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-4565","authenticated-orcid":true,"given":"J\u00e9r\u00e9mie","family":"Lefebvre","sequence":"first","affiliation":[{"name":"Krembil Research Institute, Toronto, 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