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The functional properties of mature postnatally generated neurons often match those of their embryonically produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation: the axon initial segment (AIS). Large AIS-positive axon-bearing DA neurons are exclusively produced during early embryonic stages, leaving small anaxonic AIS-negative cells as the only DA subtype generated via adult neurogenesis. These populations are functionally distinct: large DA cells are more excitable, yet display weaker and \u2013 for certain long-latency or inhibitory events \u2013 more broadly tuned responses to odorant stimuli. Embryonic and postnatal neurogenesis can therefore generate distinct neuronal subclasses, placing important constraints on the functional roles of adult-born neurons in sensory processing.<\/jats:p>","DOI":"10.7554\/elife.32373","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T09:11:16Z","timestamp":1524129076000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.32373","source":"Crossref","is-referenced-by-count":58,"title":["Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6941-766X","authenticated-orcid":true,"given":"Elisa","family":"Galliano","sequence":"first","affiliation":[{"name":"Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London","place":["London, United Kingdom"]},{"name":"Department of Molecular and Cellular Biology, Harvard 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