{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:08:42Z","timestamp":1792246122846,"version":"4.4.0"},"reference-count":59,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001033","name":"Jane Coffin Childs Memorial Fund for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS034389"],"award-info":[{"award-number":["NS034389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009784","name":"Starr Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS081706"],"award-info":[{"award-number":["NS081706"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35NS097404"],"award-info":[{"award-number":["R35NS097404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked to autoimmunity and cancer, but functions in adaptive immunity are less clear. We used HITS-CLIP to define ZFP36 targets in mouse T cells, revealing unanticipated actions in regulating T-cell activation, proliferation, and effector functions. Transcriptome and ribosome profiling showed that ZFP36 represses mRNA target abundance and translation, notably through novel AU-rich sites in coding sequence. Functional studies revealed that ZFP36 regulates early T-cell activation kinetics cell autonomously, by attenuating activation marker expression, limiting T cell expansion, and promoting apoptosis. Strikingly, loss of ZFP36 in vivo accelerated T cell responses to acute viral infection and enhanced anti-viral immunity. These findings uncover a critical role for ZFP36 RBPs in restraining T cell expansion and effector functions, and suggest ZFP36 inhibition as a strategy to enhance immune-based therapies.<\/jats:p>","DOI":"10.7554\/elife.33057","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T08:00:19Z","timestamp":1527753619000},"source":"Crossref","is-referenced-by-count":157,"title":["ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-083X","authenticated-orcid":true,"given":"Michael J","family":"Moore","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie E","family":"Blachere","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Fak","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Y","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"},{"name":"New York Genome Center, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Sawicka","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salina","family":"Parveen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Zucker-Scharff","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Moltedo","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Y","family":"Rudensky","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-8088","authenticated-orcid":true,"given":"Robert B","family":"Darnell","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States"},{"name":"New York Genome Center, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.18129\/B9.bioc.topGO","article-title":"topGO: Enrichment Analysis for Gene Ontology","author":"Alexa","year":"2016","unstructured":"Alexa A, Rahnenfuhrer J. 2016. topGO: Enrichment Analysis for Gene Ontology. R package version 2.32.0."},{"key":"bib2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1042\/bst0300945","article-title":"Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover","volume":"30","author":"Blackshear","year":"2002","journal-title":"Biochemical Society Transactions"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"27870","DOI":"10.1074\/jbc.M402551200","article-title":"RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs","volume":"279","author":"Brewer","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbagrm.2013.02.003","article-title":"Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action","volume":"1829","author":"Brooks","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0003-9861(03)00012-2","article-title":"Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases","volume":"412","author":"Cao","year":"2003","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"13724","DOI":"10.1021\/bi049014y","article-title":"Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications","volume":"43","author":"Cao","year":"2004","journal-title":"Biochemistry"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1073\/pnas.83.6.1670","article-title":"Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators","volume":"83","author":"Caput","year":"1986","journal-title":"PNAS"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.281.5379.1001","article-title":"Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin","volume":"281","author":"Carballo","year":"1998","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"8471","DOI":"10.1128\/MCB.14.12.8471","article-title":"Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements","volume":"14","author":"Chen","year":"1994","journal-title":"Molecular and Cellular Biology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.immuni.2014.01.005","article-title":"Molecular and transcriptional basis of CD4\u207a T cell dysfunction during chronic infection","volume":"40","author":"Crawford","year":"2014","journal-title":"Immunity"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1099\/0022-1317-64-8-1689","article-title":"Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains","volume":"64","author":"Dutko","year":"1983","journal-title":"Journal of General Virology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nsmb.2572","article-title":"Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin","volume":"20","author":"Fabian","year":"2013","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1126\/science.aad5978","article-title":"RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence","volume":"352","author":"Galloway","year":"2016","journal-title":"Science"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/ni.1699","article-title":"The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules","volume":"10","author":"Hao","year":"2009","journal-title":"Nature Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.4049\/jimmunol.178.5.2961","article-title":"Regulatory T cells dynamically control the primary immune response to foreign antigen","volume":"178","author":"Haribhai","year":"2007","journal-title":"The Journal of Immunology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Molecular Cell"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ni.1901","article-title":"Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia","volume":"11","author":"Hodson","year":"2010","journal-title":"Nature Immunology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"Journal of Experimental Medicine"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ni.2884","article-title":"Post-transcriptional coordination of immunological responses by RNA-binding proteins","volume":"15","author":"Kafasla","year":"2014","journal-title":"Nature Immunology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/msb.2011.93","article-title":"Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation","volume":"7","author":"Kratochvill","year":"2011","journal-title":"Molecular Systems Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"25266","DOI":"10.1074\/jbc.270.42.25266","article-title":"Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin","volume":"270","author":"Lai","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nature Methods"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Computational Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.febslet.2011.11.021","article-title":"Tristetraprolin down-regulates IL-17 through mRNA destabilization","volume":"586","author":"Lee","year":"2012","journal-title":"FEBS Letters"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nature07488","article-title":"HITS-CLIP yields genome-wide insights into brain alternative RNA processing","volume":"456","author":"Licatalosi","year":"2008","journal-title":"Nature"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1101\/gad.1282305","article-title":"Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1","volume":"19","author":"Lykke-Andersen","year":"2005","journal-title":"Genes & Development"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1128\/JVI.68.12.8056-8063.1994","article-title":"CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection","volume":"68","author":"Matloubian","year":"1994","journal-title":"Journal of Virology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nprot.2014.012","article-title":"Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis","volume":"9","author":"Moore","year":"2014","journal-title":"Nature Protocols"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S0076-6879(03)70037-8","article-title":"Immunoaffinity purification of mammalian protein complexes","volume":"370","author":"Nakatani","year":"2003","journal-title":"Methods in Enzymology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.4049\/jimmunol.174.2.953","article-title":"Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay","volume":"174","author":"Ogilvie","year":"2005","journal-title":"The Journal of Immunology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"11216","DOI":"10.1074\/jbc.M901229200","article-title":"Tristetraprolin mediates interferon-gamma mRNA decay","volume":"284","author":"Ogilvie","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.tips.2016.07.002","article-title":"Tristetraprolin as a therapeutic target in inflammatory disease","volume":"37","author":"Patial","year":"2016","journal-title":"Trends in Pharmacological Sciences"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1128\/MCB.05340-11","article-title":"AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK\/P54","volume":"32","author":"Qi","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"5150","DOI":"10.4049\/jimmunol.1103700","article-title":"Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype","volume":"188","author":"Qiu","year":"2012","journal-title":"The Journal of Immunology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"47958","DOI":"10.1074\/jbc.M109511200","article-title":"HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities","volume":"276","author":"Raghavan","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.cell.2012.06.033","article-title":"Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state","volume":"150","author":"Rounbehler","year":"2012","journal-title":"Cell"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview--extensible visualization of microarray data","volume":"20","author":"Saldanha","year":"2004","journal-title":"Bioinformatics"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"868","DOI":"10.15252\/msb.20156628","article-title":"Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation\u00a0resolution","volume":"12","author":"Sedlyarov","year":"2016","journal-title":"Molecular Systems Biology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1093\/bioinformatics\/btw653","article-title":"CLIP tool kit (CTK): a flexible and robust pipeline to analyze CLIP sequencing data","volume":"33","author":"Shah","year":"2017","journal-title":"Bioinformatics"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0092-8674(86)90341-7","article-title":"A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation","volume":"46","author":"Shaw","year":"1986","journal-title":"Cell"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.bbagrm.2013.04.002","article-title":"RNA decay mechanisms: specificity through diversity","volume":"1829","author":"Stoecklin","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1128\/MCB.00845-15","article-title":"Tristetraprolin recruits eukaryotic initiation factor 4E2 to repress translation of AU-rich element-containing mRNAs","volume":"35","author":"Tao","year":"2015","journal-title":"Molecular and Cellular Biology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S1074-7613(00)80411-2","article-title":"A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency","volume":"4","author":"Taylor","year":"1996","journal-title":"Immunity"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e1000457","DOI":"10.1371\/journal.ppat.1000457","article-title":"Viral sequestration of antigen subverts cross presentation to CD8(+) T cells","volume":"5","author":"Tewalt","year":"2009","journal-title":"PLoS Pathogens"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"7418","DOI":"10.1093\/nar\/gkw474","article-title":"The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation","volume":"44","author":"Tiedje","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"e1002977","DOI":"10.1371\/journal.pgen.1002977","article-title":"The p38\/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation","volume":"8","author":"Tiedje","year":"2012","journal-title":"PLoS Genetics"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1126\/science.1090095","article-title":"CLIP identifies Nova-regulated RNA networks in the brain","volume":"302","author":"Ule","year":"2003","journal-title":"Science"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1101\/gad.1298605","article-title":"Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition","volume":"19","author":"Venkataraman","year":"2005","journal-title":"Genes & Development"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.4049\/jimmunol.1600854","article-title":"The RNA-Binding proteins Zfp36l1 and Zfp36l2 enforce the thymic \u03b2-Selection checkpoint by limiting DNA damage response signaling and cell cycle progression","volume":"197","author":"Vogel","year":"2016","journal-title":"The Journal of Immunology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/wrna.55","article-title":"Turnover of AU-rich-containing mRNAs during stress: a matter of survival","volume":"2","author":"von Roretz","year":"2011","journal-title":"Wiley Interdisciplinary Reviews: RNA"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.celrep.2014.02.005","article-title":"HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism","volume":"6","author":"Weyn-Vanhentenryck","year":"2014","journal-title":"Cell Reports"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"48558","DOI":"10.1074\/jbc.M206505200","article-title":"RNA binding properties of the AU-rich element-binding recombinant Nup475\/TIS11\/tristetraprolin protein","volume":"277","author":"Worthington","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature11981","article-title":"Dynamic regulatory network controlling TH17 cell differentiation","volume":"496","author":"Yosef","year":"2013","journal-title":"Nature"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/33057\/elife-33057-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/33057\/elife-33057-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/33057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:50:57Z","timestamp":1697057457000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/33057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":59,"alternative-id":["10.7554\/eLife.33057"],"URL":"https:\/\/doi.org\/10.7554\/elife.33057","archive":["CLOCKSS"],"relation":{"references":[{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE43970","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE96076","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.33057.035","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.33057.034","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/247668","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"article-number":"e33057"}}