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However, this RT demonstrates extremely high variability which, in spite of extensive research, remains unexplained. It is well established that, when a visual target appears, oculomotor activity gradually builds up until a critical level is reached, at which point a saccade is triggered. Here, based on computational work and single-neuron recordings from monkey frontal eye field (FEF), we show that this rise-to-threshold process starts from a dynamic initial state that already contains other incipient, internally driven motor plans, which compete with the target-driven activity to varying degrees. The ensuing conflict resolution process, which manifests in subtle covariations between baseline activity, build-up rate, and threshold, consists of fundamentally deterministic interactions, and explains the observed RT distributions while invoking only a small amount of intrinsic randomness.<\/jats:p>","DOI":"10.7554\/elife.33456","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T08:00:17Z","timestamp":1523606417000},"source":"Crossref","is-referenced-by-count":35,"title":["Motor selection dynamics in FEF explain the reaction time variance of saccades to single targets"],"prefix":"10.7554","volume":"7","author":[{"given":"Christopher K","family":"Hauser","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dantong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence R","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-5693","authenticated-orcid":true,"given":"Emilio","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.neuron.2011.05.047","article-title":"Single-trial neural correlates of arm movement preparation","volume":"71","author":"Afshar","year":"2011","journal-title":"Neuron"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.neuron.2013.11.003","article-title":"Neural dynamics of reaching following incorrect or absent motor preparation","volume":"81","author":"Ames","year":"2014","journal-title":"Neuron"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tins.2009.09.002","article-title":"The neural basis of the speed-accuracy tradeoff","volume":"33","author":"Bogacz","year":"2010","journal-title":"Trends in Neurosciences"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"12501","DOI":"10.1523\/JNEUROSCI.2234-11.2011","article-title":"Saccadic inhibition reveals the timing of automatic and voluntary signals in the human brain","volume":"31","author":"Bompas","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00221-008-1455-0","article-title":"Relation of frontal eye field activity to saccade initiation during a countermanding task","volume":"190","author":"Brown","year":"2008","journal-title":"Experimental Brain Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cogpsych.2007.12.002","article-title":"The simplest complete model of choice response time: linear ballistic accumulation","volume":"57","author":"Brown","year":"2008","journal-title":"Cognitive Psychology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1152\/jn.1985.53.3.603","article-title":"Primate frontal eye fields. 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