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The mechanism of DBS benefits has been elusive, however, so we assessed changes in gene expression, splice isoforms, DNA methylation, and proteome following acute forniceal DBS in wild-type mice and mice lacking Mecp2. We found that DBS upregulates genes involved in synaptic function, cell survival, and neurogenesis and normalized expression of ~25% of the genes altered in Mecp2-null mice. Moreover, DBS induced expression of 17\u201324% of the genes downregulated in other intellectual disability mouse models and in post-mortem human brain tissue from patients with Major Depressive Disorder, suggesting forniceal DBS could benefit individuals with a variety of neuropsychiatric disorders.<\/jats:p>","DOI":"10.7554\/elife.34031","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T09:03:54Z","timestamp":1521795834000},"source":"Crossref","is-referenced-by-count":59,"title":["Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-7995","authenticated-orcid":true,"given":"Amy E","family":"Pohodich","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, United States"},{"name":"Jan and Dan Duncan Neurological Research Institute, Texas 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