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We treated SOD1-G93A mice with an agonist antibody to MuSK, a receptor tyrosine kinase essential for maintaining neuromuscular synapses, to determine whether increasing muscle retrograde signaling would slow nerve terminal detachment from muscle. The agonist antibody, delivered after disease onset, slowed muscle denervation, promoting motor neuron survival, improving motor system output, and extending the lifespan of SOD1-G93A mice. These findings suggest a novel therapeutic strategy for ALS, using an antibody format with clinical precedence, which targets a pathway essential for maintaining attachment of nerve terminals to muscle.<\/jats:p>","DOI":"10.7554\/elife.34375","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T19:20:28Z","timestamp":1519068028000},"source":"Crossref","is-referenced-by-count":89,"title":["Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-3729","authenticated-orcid":true,"given":"Sarah","family":"Cantor","sequence":"first","affiliation":[{"name":"Molecular Neurobiology Program, Helen L. and Martin S. 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