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Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis of the metabolic transcription factor C\/EBP\u03b2-LIP is stimulated by mTORC1, which critically depends on a short upstream open reading frame (uORF) in the Cebpb-mRNA. Here, we describe that reduced C\/EBP\u03b2-LIP expression due to genetic ablation of the uORF delays the development of age-associated phenotypes in mice. Moreover, female C\/EBP\u03b2\u0394uORF mice display an extended lifespan. Since LIP levels increase upon aging in wild type mice, our data reveal an important role for C\/EBP\u03b2 in the aging process and suggest that restriction of LIP expression sustains health and fitness. Thus, therapeutic strategies targeting C\/EBP\u03b2-LIP may offer new possibilities to treat age-related diseases and to prolong healthspan.<\/jats:p>","DOI":"10.7554\/elife.34985","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T08:00:30Z","timestamp":1525075230000},"source":"Crossref","is-referenced-by-count":27,"title":["Reduced expression of C\/EBP\u03b2-LIP extends health and lifespan in mice"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-4053","authenticated-orcid":true,"given":"Christine","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands"},{"name":"Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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