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Despite the therapeutic and scientific interest in LSD, specific receptor contributions to its neurobiological effects remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We therefore conducted a double-blind, randomized, counterbalanced, cross-over studyduring which 24 healthy human participants received either (i) placebo+placebo, (ii) placebo+LSD (100 \u00b5g po), or (iii) Ketanserin, a selective 5-HT2A receptor antagonist,+LSD. We quantified resting-state functional connectivity via a data-driven global brain connectivity method and compared it to cortical gene expression maps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>LSD reduced associative, but concurrently increased sensory-somatomotor brain-wide and thalamic connectivity. Ketanserin fully blocked the subjective and neural LSD effects. Whole-brain spatial patterns of LSD effects matched 5-HT2A receptor cortical gene expression in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Together, these results strongly implicate the 5-HT2A receptor in LSD\u2019s neuropharmacology. This study therefore pinpoints the critical role of 5-HT2A in LSD\u2019s mechanism, which informs its neurobiology and guides rational development of psychedelic-based therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs5\">\n                    <jats:title>Funding:<\/jats:title>\n                    <jats:p>Funded by the Swiss National Science Foundation, the Swiss Neuromatrix Foundation, the Usona Institute, the NIH, the NIAA, the NARSAD Independent Investigator Grant, the Yale CTSA grant, and the Slovenian Research Agency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs6\">\n                    <jats:title>Clinical trial number:<\/jats:title>\n                    <jats:p>\n                      <jats:related-object document-id=\"NCT02451072\" document-id-type=\"clinical-trial-number\" id=\"RO1\" source-id=\"ClinicalTrials.gov\" source-id-type=\"registry-name\" source-type=\"clinical-trials-registry\" xlink:href=\"https:\/\/clinicaltrials.gov\/show\/NCT02451072\">NCT02451072<\/jats:related-object>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.7554\/elife.35082","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T07:00:50Z","timestamp":1540450850000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.35082","source":"Crossref","is-referenced-by-count":402,"title":["Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor"],"prefix":"10.7554","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct02451072","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-7672","authenticated-orcid":true,"given":"Katrin H","family":"Preller","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and 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