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Here, we report that the protocadherin alpha (Pcdha) gene cluster regulates neuronal migration during cortical development and cytoskeletal dynamics in primary cortical culture through the WAVE (Wiskott-Aldrich syndrome family verprolin homologous protein, also known as Wasf) complex. In addition, overexpression of proline-rich tyrosine kinase 2 (Pyk2, also known as Ptk2b, Cak\u03b2, Raftk, Fak2, and Cadtk), a non-receptor cell-adhesion kinase and scaffold protein downstream of Pcdh\u03b1, impairs cortical neuron migration via inactivation of the small GTPase Rac1. Thus, we define a molecular Pcdh\u03b1\/WAVE\/Pyk2\/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain.<\/jats:p>","DOI":"10.7554\/elife.35242","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T08:01:19Z","timestamp":1529308879000},"source":"Crossref","is-referenced-by-count":67,"title":["Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice"],"prefix":"10.7554","volume":"7","author":[{"given":"Li","family":"Fan","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biomedicine (Ministry of Education), Center for Comparative Biomedicine, Institute of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, 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