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To identify principles underlying biological order, we turned to C. elegans for its simple anatomy and powerful genetics. We developed a method to quantify the arrangement of three dendrites in the main sensory nerve bundle, and found that they exhibit a stereotyped arrangement throughout larval growth. Dendrite order does not require prominent features including sensory cilia and glial junctions. In contrast, loss of the cell adhesion molecule (CAM) CDH-4\/Fat-like cadherin causes dendrites to be ordered randomly, despite remaining bundled. Loss of the CAMs PTP-3\/LAR or SAX-7\/L1CAM causes dendrites to adopt an altered order, which becomes increasingly random as animals grow. Misexpression of SAX-7 leads to subtle but reproducible changes in dendrite order. Our results suggest that combinations of CAMs allow dendrites to self-organize into a stereotyped arrangement and can produce altered patterns when perturbed.<\/jats:p>","DOI":"10.7554\/elife.35825","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T08:01:33Z","timestamp":1534492893000},"source":"Crossref","is-referenced-by-count":21,"title":["Ordered arrangement of dendrites within a C. elegans sensory nerve bundle"],"prefix":"10.7554","volume":"7","author":[{"given":"Zhiqi Candice","family":"Yip","sequence":"first","affiliation":[{"name":"Division of Genetics and Genomics, Boston Children\u2019s Hospital, Boston, United States"},{"name":"Department of Genetics, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-6490","authenticated-orcid":true,"given":"Maxwell G","family":"Heiman","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomics, Boston Children\u2019s Hospital, Boston, United States"},{"name":"Department of Genetics, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"7517","DOI":"10.1523\/JNEUROSCI.2010-05.2005","article-title":"The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation","volume":"25","author":"Ackley","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"bib2","article-title":"Slice No. 18 and\u00a050","volume-title":"SW-Worm Viewer","author":"Altun","year":"2005","unstructured":"Altun ZF, Hall DH. 2005. 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