{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:46:21Z","timestamp":1791726381819,"version":"4.3.4"},"reference-count":87,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011699","name":"BRACE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K004360\/1"],"award-info":[{"award-number":["MR\/K004360\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K501086\/1"],"award-info":[{"award-number":["MR\/K501086\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K005464\/1"],"award-info":[{"award-number":["MR\/K005464\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["WT105613\/Z\/14\/Z"],"award-info":[{"award-number":["WT105613\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-\u025b4, the greatest genetic risk for Alzheimer\u2019s disease (AD). Connectivity across frequencies, but most prevalent in alpha\/beta, was increased in APOE-\u025b4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40\u2013160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-\u025b4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity, while young APOE-e4 carriers could also be distinguished from their controls with above chance performance. These results support theories of initial hyperconnectivity driving eventual profound disconnection in AD and suggest that this is present decades before the onset of AD symptomology.<\/jats:p>","DOI":"10.7554\/elife.36011","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T06:02:41Z","timestamp":1556604161000},"source":"Crossref","is-referenced-by-count":116,"title":["Oscillatory hyperactivity and hyperconnectivity in young APOE-\u025b4 carriers and hypoconnectivity in Alzheimer\u2019s disease"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-171X","authenticated-orcid":true,"given":"Loes","family":"Koelewijn","sequence":"first","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"},{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom"},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Linden","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"},{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom"},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-5574","authenticated-orcid":true,"given":"Diana C","family":"Dima","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany C","family":"Routley","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-8374","authenticated-orcid":true,"given":"Lorenzo","family":"Magazzini","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali","family":"Barawi","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Brindley","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Adams","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-3376","authenticated-orcid":true,"given":"Katherine E","family":"Tansey","sequence":"additional","affiliation":[{"name":"Core Bioinformatics and Statistics Team, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Bompas","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tales","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Human and Health Sciences, Swansea University, Swansea, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Bayer","sequence":"additional","affiliation":[{"name":"School of Medicine, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-2475","authenticated-orcid":true,"given":"Krish","family":"Singh","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom"},{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ana.20724","article-title":"Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study","volume":"59","author":"Babiloni","year":"2006","journal-title":"Annals of Neurology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nn.4504","article-title":"Magnetoencephalography for brain electrophysiology and imaging","volume":"20","author":"Baillet","year":"2017","journal-title":"Nature Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"The Annals of Statistics"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1145\/130385.130401","article-title":"A training algorithm for optimal margin classifiers","author":"Boser","year":"1992","journal-title":"In Proceedings of the Fifth Annual Workshop on Computational Learning Theory"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.neuroimage.2013.11.047","article-title":"Exploring mechanisms of spontaneous functional connectivity in MEG: how delayed network interactions lead to structured amplitude envelopes of band-pass filtered oscillations","volume":"90","author":"Cabral","year":"2014","journal-title":"NeuroImage"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046289","article-title":"Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study","volume":"7","author":"Canuet","year":"2012","journal-title":"PLoS ONE"},{"key":"bib9","article-title":"Basic functions for power analysis","volume-title":"R Package Version","author":"Champely","year":"2018","unstructured":"Champely S, Ekstrom C, Dalgaard P, Gill J, Wunder J, De Rosario H. 2018. Basic functions for power analysis. R Package Version. https:\/\/cran.r-project.org\/web\/packages\/pwr\/pwr.pdf."},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.neuroimage.2015.03.071","article-title":"A symmetric multivariate leakage correction for MEG connectomes","volume":"117","author":"Colclough","year":"2015","journal-title":"NeuroImage"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.neuroimage.2016.05.070","article-title":"How reliable are MEG resting-state connectivity metrics?","volume":"138","author":"Colclough","year":"2016","journal-title":"NeuroImage"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1093\/hmg\/ddq221","article-title":"Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals","volume":"19","author":"Corneveaux","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3233\/JAD-141872","article-title":"Influence of the APOE \u03b54 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space","volume":"44","author":"Cuesta","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \"default network\" in normal aging","volume":"18","author":"Damoiseaux","year":"2008","journal-title":"Cerebral Cortex"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nature Genetics"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002582","article-title":"Activity dependent degeneration explains hub vulnerability in Alzheimer's disease","volume":"8","author":"de Haan","year":"2012","journal-title":"PLoS Computational Biology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/j.neuroimage.2011.11.055","article-title":"Disrupted modular brain dynamics reflect cognitive dysfunction in Alzheimer's disease","volume":"59","author":"de Haan","year":"2012","journal-title":"NeuroImage"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1016\/j.neurobiolaging.2013.03.007","article-title":"Alzheimer's disease patients not carrying the apolipoprotein E \u03b54 allele show more severe slowing of oscillatory brain activity","volume":"34","author":"de Waal","year":"2013","journal-title":"Neurobiology of Aging"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tics.2011.03.007","article-title":"A framework for local cortical oscillation patterns","volume":"15","author":"Donner","year":"2011","journal-title":"Trends in Cognitive Sciences"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1212\/WNL.0b013e3181a2e8d0","article-title":"Effect of APOE genotype on amyloid plaque load and gray matter volume in alzheimer disease","volume":"72","author":"Drzezga","year":"2009","journal-title":"Neurology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neulet.2009.07.032","article-title":"ApoE 4 reduces the expression of abeta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons","volume":"464","author":"Du","year":"2009","journal-title":"Neuroscience Letters"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1093\/brain\/awv268","article-title":"Common polygenic variation enhances risk prediction for alzheimer's disease","volume":"138","author":"Escott-Price","year":"2015","journal-title":"Brain"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuroimage.2017.09.009","article-title":"Adaptive cortical parcellations for source reconstructed EEG\/MEG connectomes","volume":"169","author":"Farahibozorg","year":"2018","journal-title":"NeuroImage"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1097\/01.wnr.0000234745.27571.d1","article-title":"Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults","volume":"17","author":"Filbey","year":"2006","journal-title":"NeuroReport"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"PNAS"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.neuroimage.2008.10.003","article-title":"Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease","volume":"44","author":"Filippini","year":"2009","journal-title":"NeuroImage"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.pneurobio.2010.11.005","article-title":"Biomarkers for alzheimer's disease therapeutic trials","volume":"95","author":"Hampel","year":"2011","journal-title":"Progress in Neurobiology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/mp.2010.90","article-title":"The APOE \u025b4 allele modulates brain white matter integrity in healthy adults","volume":"16","author":"Heise","year":"2011","journal-title":"Molecular Psychiatry"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/nn.4017","article-title":"The case for rejecting the amyloid cascade hypothesis","volume":"18","author":"Herrup","year":"2015","journal-title":"Nature Neuroscience"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1016\/j.neuroimage.2011.11.005","article-title":"Frequency-dependent functional connectivity within resting-state networks: an atlas-based MEG beamformer solution","volume":"59","author":"Hillebrand","year":"2012","journal-title":"NeuroImage"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1073\/pnas.1515657113","article-title":"Direction of information flow in large-scale resting-state networks is frequency-dependent","volume":"113","author":"Hillebrand","year":"2016","journal-title":"PNAS"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2018.08.026","article-title":"Increased posterior default mode network activity and structural connectivity in young adult APOE-\u03b54 carriers: a multimodal imaging investigation","volume":"73","author":"Hodgetts","year":"2019","journal-title":"Neurobiology of Aging"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"13510","DOI":"10.1073\/pnas.1608587113","article-title":"Relationships between cortical myeloarchitecture and electrophysiological networks","volume":"113","author":"Hunt","year":"2016","journal-title":"PNAS"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1136\/jnnp.63.1.59","article-title":"Apolipoprotein E epsilon4 allele decreases functional connectivity in Alzheimer's disease as measured by EEG coherence","volume":"63","author":"Jelic","year":"1997","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1136\/jnnp.65.3.322","article-title":"Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon 4 allele","volume":"65","author":"Juottonen","year":"1998","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and a\u03b2 in Alzheimer's disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.arr.2016.02.003","article-title":"Brain fluorodeoxyglucose (FDG) PET in dementia","volume":"30","author":"Kato","year":"2016","journal-title":"Ageing Research Reviews"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1176\/appi.ajp.2007.07010043","article-title":"The MATRICS consensus cognitive battery, part 2: co-norming and standardization","volume":"165","author":"Kern","year":"2008","journal-title":"American Journal of Psychiatry"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1016\/j.clinph.2017.04.018","article-title":"Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity","volume":"128","author":"Koelewijn","year":"2017","journal-title":"Clinical Neurophysiology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/ana.21696","article-title":"Apolipoprotein E-dependent accumulation of alzheimer disease-related lesions begins in middle age","volume":"65","author":"Kok","year":"2009","journal-title":"Annals of Neurology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1016\/j.clinph.2008.08.019","article-title":"EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls","volume":"119","author":"Kramer","year":"2008","journal-title":"Clinical Neurophysiology"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22978","article-title":"Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline","volume":"6","author":"Leal","year":"2017","journal-title":"eLife"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/ng.3679","article-title":"Reference-based phasing using the haplotype reference consortium panel","volume":"48","author":"Loh","year":"2016","journal-title":"Nature Genetics"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.nicl.2015.07.011","article-title":"A multicenter study of the early detection of synaptic dysfunction in mild cognitive impairment using Magnetoencephalography-derived functional connectivity","volume":"9","author":"Maest\u00fa","year":"2015","journal-title":"NeuroImage: Clinical"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/ng.3643","article-title":"A reference panel of 64,976 haplotypes for genotype imputation","volume":"48","author":"McCarthy","year":"2016","journal-title":"Nature Genetics"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/ana.21843","article-title":"APOE predicts amyloid-beta but not tau alzheimer pathology in cognitively normal aging","volume":"67","author":"Morris","year":"2010","journal-title":"Annals of Neurology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1093\/brain\/awu103","article-title":"Within-patient correspondence of amyloid-\u03b2 and intrinsic network connectivity in Alzheimer's disease","volume":"137","author":"Myers","year":"2014","journal-title":"Brain"},{"key":"bib52","first-page":"1","article-title":"Nonparametric permutation tests for functional neuroimaging","volume":"15","author":"Nichols","year":"2003","journal-title":"Human Brain Function"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1088\/0031-9155\/48\/22\/002","article-title":"The magnetic lead field theorem in the quasi-static approximation and its use for magnetoencephalography forward calculation in realistic volume conductors","volume":"48","author":"Nolte","year":"2003","journal-title":"Physics in Medicine and Biology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1176\/appi.ajp.2007.07010042","article-title":"The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity","volume":"165","author":"Nuechterlein","year":"2008","journal-title":"American Journal of Psychiatry"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01444-0","article-title":"Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking alzheimer's disease-like pathology","volume":"8","author":"Nuriel","year":"2017","journal-title":"Nature Communications"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1212\/WNL.0b013e3181e3966e","article-title":"Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline","volume":"74","author":"O'Brien","year":"2010","journal-title":"Neurology"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048895","article-title":"Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study","volume":"7","author":"O'Dwyer","year":"2012","journal-title":"PLoS ONE"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Computational Intelligence and Neuroscience"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/acn3.280","article-title":"Reduced brain connectivity and mental flexibility in mild traumatic brain injury","volume":"3","author":"Pang","year":"2016","journal-title":"Annals of Clinical and Translational Neurology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1001\/jama.1995.03520400044042","article-title":"Apolipoprotein E status as a predictor of the development of Alzheimer's Disease in Memory-Impaired Individuals","volume":"273","author":"Petersen","year":"1995","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.neurobiolaging.2006.12.019","article-title":"EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of alzheimer disease","volume":"29","author":"Ponomareva","year":"2008","journal-title":"Neurobiology of Aging"},{"key":"bib63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000610","article-title":"Different origins of gamma rhythm and high-gamma activity in macaque visual cortex","volume":"9","author":"Ray","year":"2011","journal-title":"PLoS Biology"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"6820","DOI":"10.1073\/pnas.0900345106","article-title":"Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for alzheimer's disease","volume":"106","author":"Reiman","year":"2009","journal-title":"PNAS"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.neubiorev.2013.05.006","article-title":"APOE-related biomarker profiles in non-pathological aging and early phases of alzheimer's disease","volume":"37","author":"Reinvang","year":"2013","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1177\/0269881117736915","article-title":"The effects of AMPA receptor blockade on resting magnetoencephalography recordings","volume":"31","author":"Routley","year":"2017","journal-title":"Journal of Psychopharmacology"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1037\/1082-989X.13.1.19","article-title":"A probability-based measure of effect size: robustness to base rates and other factors","volume":"13","author":"Ruscio","year":"2008","journal-title":"Psychological Methods"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrn1650","article-title":"Normal and pathological oscillatory communication in the brain","volume":"6","author":"Schnitzler","year":"2005","journal-title":"Nature Reviews Neuroscience"},{"key":"bib69","volume-title":"SourceMesh Features. Github","author":"Shaw","year":"2019","unstructured":"Shaw A. 2019. SourceMesh Features. Github. 08aa50a. https:\/\/github.com\/alexandershaw4\/SourceMesh."},{"key":"bib70","doi-asserted-by":"publisher","first-page":"17035","DOI":"10.1523\/JNEUROSCI.3987-10.2010","article-title":"APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF a\u03b242","volume":"30","author":"Sheline","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.1038\/srep16322","article-title":"APOE-\u03b54 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults","volume":"5","author":"Shine","year":"2015","journal-title":"Scientific Reports"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuroimage.2016.01.055","article-title":"Measuring the cortical correlation structure of spontaneous oscillatory activity with EEG and MEG","volume":"129","author":"Siems","year":"2016","journal-title":"NeuroImage"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/S1053-8119(03)00249-0","article-title":"Group imaging of task-related changes in cortical synchronisation using nonparametric permutation testing","volume":"19","author":"Singh","year":"2003","journal-title":"NeuroImage"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2014.08.014","article-title":"Storm before the quiet: neuronal hyperactivity and a\u03b2 in the presymptomatic stages of Alzheimer's disease","volume":"36","author":"Stargardt","year":"2015","journal-title":"Neurobiology of Aging"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/ng.2250","article-title":"Identification of common variants associated with human hippocampal and intracranial volumes","volume":"44","author":"Stein","year":"2012","journal-title":"Nature Genetics"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1002\/hbm.20652","article-title":"Regional networks underlying interhemispheric connectivity: an EEG and DTI study in healthy ageing and amnestic mild cognitive impairment","volume":"30","author":"Teipel","year":"2009","journal-title":"Human Brain Mapping"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/j.neurobiolaging.2013.02.020","article-title":"Alzheimer's disease: connecting findings from graph theoretical studies of brain networks","volume":"34","author":"Tijms","year":"2013","journal-title":"Neurobiology of Aging"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/S1474-4422(10)70306-9","article-title":"Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE \u025b4 allele","volume":"10","author":"van der Flier","year":"2011","journal-title":"The Lancet Neurology"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neuroimage.2015.11.047","article-title":"Spectrally resolved fast transient brain states in electrophysiological data","volume":"126","author":"Vidaurre","year":"2016","journal-title":"NeuroImage"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/meth.2001.1238","article-title":"Signal processing in magnetoencephalography","volume":"25","author":"Vrba","year":"2001","journal-title":"Methods"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1523\/JNEUROSCI.1230-11.2011","article-title":"Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE \u03b54 carriers: relationships with memory performance","volume":"31","author":"Westlye","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"NeuroImage"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1212\/01.wnl.0000238079.00472.3a","article-title":"Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele","volume":"67","author":"Wishart","year":"2006","journal-title":"Neurology"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"18700","DOI":"10.1073\/pnas.0508693102","article-title":"Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoe structure as a potential therapeutic target","volume":"102","author":"Ye","year":"2005","journal-title":"PNAS"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.biopsych.2017.03.003","article-title":"Apolipoprotein E, receptors, and modulation of alzheimer's Disease","volume":"83","author":"Zhao","year":"2018","journal-title":"Biological Psychiatry"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/36011\/elife-36011-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/36011\/elife-36011-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/36011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:49:43Z","timestamp":1697057383000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/36011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":87,"alternative-id":["10.7554\/eLife.36011"],"URL":"https:\/\/doi.org\/10.7554\/elife.36011","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17605\/OSF.IO\/E4CJX","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.36011.016","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.36011.015","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735639196.793559972","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,30]]},"article-number":"e36011"}}