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This regeneration process is called ductular reaction (DR), which is accompanied by dynamic remodeling of biliary tissue. Although the DR shows apparently distinct mode of biliary extension depending on the type of liver injury, the key regulatory mechanism remains poorly understood. Here, we show that Lutheran (Lu)\/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models. Lu+ and Lu- biliary cells isolated from injured liver exhibit opposite phenotypes in cell motility and duct formation capacities in vitro. By overexpression of Lu, Lu- biliary cells acquire the phenotype of Lu+ biliary cells. Lu-deficient mice showed severe defects in DR. Our findings reveal a critical role of Lu in the control of phenotypic heterogeneity of DR in distinct liver disease models.<\/jats:p>","DOI":"10.7554\/elife.36572","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T08:00:36Z","timestamp":1532937636000},"source":"Crossref","is-referenced-by-count":12,"title":["Differential expression of Lutheran\/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration"],"prefix":"10.7554","volume":"7","author":[{"given":"Yasushi","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan"},{"name":"Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 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