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A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary discharge, CD) to the cerebellum. We tested this possibility by recording from two precerebellar nuclei\u2014the inferior olive (IO) and lateral reticular nucleus (LRN). In most IO and LRN neurons, twitch-related activity peaked sharply around twitch onset, consistent with CD. Next, we identified twitch-production areas in the midbrain that project independently to the IO and LRN. Finally, we blocked calcium-activated slow potassium (SK) channels in the IO to explain how broadly tuned brainstem motor signals can be transformed into precise CD signals. We conclude that the precerebellar nuclei convey a diversity of sleep-related neural activity to the developing cerebellum to enable processing of convergent input from CD and reafferent signals.<\/jats:p>","DOI":"10.7554\/elife.38213","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T10:33:57Z","timestamp":1543919637000},"source":"Crossref","is-referenced-by-count":24,"title":["Corollary discharge in precerebellar nuclei of sleeping infant rats"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-2831","authenticated-orcid":true,"given":"Didhiti","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Iowa, Iowa, United States"},{"name":"Delta Center, University of Iowa, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-1980","authenticated-orcid":true,"given":"Greta","family":"Sokoloff","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Iowa, Iowa, United States"},{"name":"Delta Center, University of Iowa, Iowa, United States"},{"name":"Iowa Neuroscience Institute, University of Iowa, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-2955","authenticated-orcid":true,"given":"Mark S","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Iowa, Iowa, United States"},{"name":"Delta Center, University of Iowa, Iowa, United States"},{"name":"Iowa Neuroscience Institute, University of Iowa, Iowa, United States"},{"name":"Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa, United States"},{"name":"Department of Biology, University of Iowa, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"9922","DOI":"10.1523\/JNEUROSCI.1781-16.2016","article-title":"The Nature of the Sensory Input to the Neonatal Rat Barrel Cortex","volume":"36","author":"Akhmetshina","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.1113\/jphysiol.2013.256669","article-title":"The lateral reticular nucleus: a precerebellar centre providing the cerebellum with overview and integration of motor functions at systems level. 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