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However, it is not well understood how these changes affect offspring health and survival. The maternal attendance patterns and immunity of South American fur seals were assessed in a rookery where hookworm disease is the main cause of pup mortality. Pups receiving higher levels of maternal attendance had a positive energy balance and a more reactive immune system. These pups were able to expel hookworms through a specific immune mediated mechanism and survived the infection. Maternal attendance was higher in years with low sea surface temperature, therefore, the mean hookworm burden and mortality increased with sea surface temperature over a 10-year period. We provide a mechanistic explanation regarding how changes in ocean temperature and maternal care affect infectious diseases dynamics in a marine mammal.<\/jats:p>","DOI":"10.7554\/elife.38432","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T19:00:16Z","timestamp":1541444416000},"source":"Crossref","is-referenced-by-count":21,"title":["Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-236X","authenticated-orcid":true,"given":"Mauricio","family":"Seguel","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Montalva","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Perez-Venegas","sequence":"additional","affiliation":[{"name":"PhD Program in Conservation Medicine, Facultad de Ecolog\u00eda y Recursos Naturales, Universidad Andr\u00e9s Bello, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Programa de Investigaci\u00f3n Aplicada en Fauna Silvestre, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile"},{"name":"Facultad de Ciencias Veterinarias, Instituto de Patolog\u00eda Animal, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector J","family":"Paves","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Universidad Santo Tomas, Osorno, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Cl\u00ednicas Veterinarias, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Valencia-Soto","sequence":"additional","affiliation":[{"name":"Programa de Investigaci\u00f3n Aplicada en Fauna Silvestre, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Howerth","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mendiola","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gottdenker","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1139\/z00-178","article-title":"Dive behaviour, foraging locations, and maternal-attendance patterns of Australian fur seals ( Arctocephalus pusillus doriferus )","volume":"79","author":"Arnould","year":"2001","journal-title":"Canadian Journal of Zoology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S1095-6433(01)00339-7","article-title":"Fasting metabolism in Antarctic fur seal (Arctocephalus gazella) pups","volume":"129","author":"Arnould","year":"2001","journal-title":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"e0179359","DOI":"10.1371\/journal.pone.0179359","article-title":"Climatic anomaly affects the immune competence of California sea lions","volume":"12","author":"Banuet-Mart\u00ednez","year":"2017","journal-title":"Plos One"},{"key":"bib4","article-title":"MuMIn: Multi-Model Inference","volume-title":"CRAN","author":"Barto\u0144","year":"2017","unstructured":"Barto\u0144 K. 2017. 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