{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:48:07Z","timestamp":1790830087841,"version":"4.1.0"},"reference-count":65,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM115313"],"award-info":[{"award-number":["T32GM115313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-16-241-01-DMC"],"award-info":[{"award-number":["RSG-16-241-01-DMC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM108119"],"award-info":[{"award-number":["GM108119"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basser Centre for BRCA"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES025166"],"award-info":[{"award-number":["ES025166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>DNA replication stress is often defined by the slowing or stalling of replication fork progression leading to local or global DNA synthesis inhibition. Failure to resolve replication stress in a timely manner contribute toward cell cycle defects, genome instability and human disease; however, the mechanism for fork recovery remains poorly defined. Here, we show that the translesion DNA polymerase (Pol) kappa, a DinB orthologue, has a unique role in both protecting and restarting stalled replication forks under conditions of nucleotide deprivation. Importantly, Pol kappa-mediated DNA synthesis during hydroxyurea (HU)-dependent fork restart is regulated by both the Fanconi Anemia (FA) pathway and PCNA polyubiquitination. Loss of Pol kappa prevents timely rescue of stalled replication forks, leading to replication-associated genomic instability, and a p53-dependent cell cycle defect. Taken together, our results identify a previously unanticipated role for Pol kappa in promoting DNA synthesis and replication stress recovery at sites of stalled forks.<\/jats:p>","DOI":"10.7554\/elife.41426","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T08:01:02Z","timestamp":1542096062000},"source":"Crossref","is-referenced-by-count":74,"title":["Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery"],"prefix":"10.7554","volume":"7","author":[{"given":"Peter","family":"Tonzi","sequence":"first","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-871X","authenticated-orcid":true,"given":"Yandong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea Wei Ting","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-5002","authenticated-orcid":true,"given":"Tony T","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.celrep.2015.04.014","article-title":"ATM couples replication stress and metabolic reprogramming during cellular senescence","volume":"11","author":"Aird","year":"2015","journal-title":"Cell Reports"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.cell.2013.01.006","article-title":"Identification of early replicating fragile sites that contribute to genome instability","volume":"152","author":"Barlow","year":"2013","journal-title":"Cell"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.dnarep.2017.05.006","article-title":"DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis","volume":"57","author":"Barnes","year":"2017","journal-title":"DNA Repair"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nsmb.2220","article-title":"Thresholds of replication stress signaling in cancer development and treatment","volume":"19","author":"Bartek","year":"2012","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1042\/BJ20141170","article-title":"SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme","volume":"468","author":"B\u00e9k\u00e9s","year":"2015","journal-title":"Biochemical Journal"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.molcel.2016.04.016","article-title":"Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease","volume":"62","author":"B\u00e9k\u00e9s","year":"2016","journal-title":"Molecular Cell"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4161\/trns.2.3.16172","article-title":"Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity?","volume":"2","author":"Bensaude","year":"2011","journal-title":"Transcription"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1038\/emboj.2013.148","article-title":"DNA polymerase \u03ba-dependent DNA synthesis at stalled replication forks is important for CHK1 activation","volume":"32","author":"B\u00e9tous","year":"2013","journal-title":"The EMBO Journal"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1126\/science.1120615","article-title":"Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis","volume":"310","author":"Bienko","year":"2005","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.dnarep.2006.04.003","article-title":"Elevated mutation rates in the germline of Polkappa mutant male mice","volume":"5","author":"Burr","year":"2006","journal-title":"DNA Repair"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.stem.2012.05.013","article-title":"Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53\/p21 DNA damage response that impairs hematopoietic stem and progenitor cells","volume":"11","author":"Ceccaldi","year":"2012","journal-title":"Cell Stem Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrm.2016.48","article-title":"The Fanconi anaemia pathway: new players and new functions","volume":"17","author":"Ceccaldi","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.molcel.2015.02.031","article-title":"ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress","volume":"58","author":"Chen","year":"2015","journal-title":"Molecular Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.molcel.2012.05.024","article-title":"Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress","volume":"47","author":"Ciccia","year":"2012","journal-title":"Molecular Cell"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4939-1680-1_10","article-title":"Purification of proteins on newly synthesized DNA using iPOND","volume":"1228","author":"Dungrawala","year":"2015","journal-title":"Methods in Molecular Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.molcel.2015.07.030","article-title":"The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability","volume":"59","author":"Dungrawala","year":"2015","journal-title":"Molecular Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway","volume":"7","author":"Garcia-Higuera","year":"2001","journal-title":"Molecular Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1101\/gad.457807","article-title":"Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress","volume":"21","author":"Ge","year":"2007","journal-title":"Genes & Development"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"9693","DOI":"10.1158\/0008-5472.CAN-10-2286","article-title":"Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner","volume":"70","author":"Gilad","year":"2010","journal-title":"Cancer Research"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/sj.emboj.7600986","article-title":"Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression","volume":"25","author":"Godoy","year":"2006","journal-title":"The EMBO Journal"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"4658","DOI":"10.1074\/jbc.M709275200","article-title":"Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance","volume":"283","author":"Guo","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1083\/jcb.201011083","article-title":"Replication stress induces 53BP1-containing OPT domains in G1 cells","volume":"193","author":"Harrigan","year":"2011","journal-title":"The Journal of Cell Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/nar\/gkm1089","article-title":"DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences","volume":"36","author":"Hile","year":"2008","journal-title":"Nucleic Acids Research"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"29361","DOI":"10.1038\/srep29361","article-title":"DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo","volume":"6","author":"Huang","year":"2016","journal-title":"Scientific Reports"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/emboj.2011.457","article-title":"Dysregulation of DNA polymerase \u03ba recruitment to replication forks results in genomic instability","volume":"31","author":"Jones","year":"2012","journal-title":"The EMBO Journal"},{"key":"bib26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1097-2765(04)00259-X","article-title":"Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage","volume":"14","author":"Kannouche","year":"2004","journal-title":"Molecular Cell"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0076-6879(06)08025-6","article-title":"Localization of Y-family polymerases and the DNA polymerase switch in mammalian cells","volume":"408","author":"Kannouche","year":"2006","journal-title":"Methods in Enzymology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"13087","DOI":"10.1038\/ncomms13087","article-title":"Increased global transcription activity as a mechanism of replication stress in cancer","volume":"7","author":"Kotsantis","year":"2016","journal-title":"Nature Communications"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature11863","article-title":"Fanconi anaemia and the repair of Watson and Crick DNA crosslinks","volume":"493","author":"Kottemann","year":"2013","journal-title":"Nature"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-4939-6670-7_2","article-title":"Senescence phenotypes induced by ras in primary cells","volume":"1534","author":"Lau","year":"2017","journal-title":"Methods in Molecular Biology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.molcel.2011.02.026","article-title":"SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis","volume":"42","author":"Lin","year":"2011","journal-title":"Molecular Cell"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molcel.2007.01.018","article-title":"Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass","volume":"25","author":"Lone","year":"2007","journal-title":"Molecular Cell"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.molcel.2013.07.023","article-title":"FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling","volume":"51","author":"Lossaint","year":"2013","journal-title":"Molecular Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/ncb2201","article-title":"53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress","volume":"13","author":"Lukas","year":"2011","journal-title":"Nature Cell Biology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature25507","article-title":"Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress","volume":"555","author":"Macheret","year":"2018","journal-title":"Nature"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"e18020","DOI":"10.7554\/eLife.18020","article-title":"Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells","volume":"5","author":"Mansilla","year":"2016","journal-title":"eLife"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.cell.2013.05.046","article-title":"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis","volume":"154","author":"Mevissen","year":"2013","journal-title":"Cell"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"909","DOI":"10.15252\/embj.201693860","article-title":"Interplay between Fanconi anemia and homologous recombination pathways in genome integrity","volume":"35","author":"Michl","year":"2016","journal-title":"The EMBO Journal"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nsmb.3252","article-title":"FANCD2 limits replication stress and genome instability in cells lacking BRCA2","volume":"23","author":"Michl","year":"2016","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"v7","DOI":"10.1093\/annonc\/mdj941","article-title":"Cellular pharmacology of gemcitabine","volume":"17","author":"Mini","year":"2006","journal-title":"Annals of Oncology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1038\/nsmb.2189","article-title":"Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors","volume":"18","author":"Murga","year":"2011","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrc.2017.116","article-title":"Fanconi anaemia and cancer: an intricate relationship","volume":"18","author":"Nalepa","year":"2018","journal-title":"Nature Reviews Cancer"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.molcel.2010.01.021","article-title":"Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair","volume":"37","author":"Petermann","year":"2010","journal-title":"Molecular Cell"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature18325","article-title":"Replication fork stability confers chemoresistance in BRCA-deficient cells","volume":"535","author":"Ray Chaudhuri","year":"2016","journal-title":"Nature"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1128\/MCB.00115-09","article-title":"Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication","volume":"29","author":"Rey","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nmeth929","article-title":"Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)","volume":"3","author":"Rust","year":"2006","journal-title":"Nature Methods"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrm3289","article-title":"Y-family DNA polymerases and their role in tolerance of cellular DNA damage","volume":"13","author":"Sale","year":"2012","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.cell.2011.03.041","article-title":"Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11","volume":"145","author":"Schlacher","year":"2011","journal-title":"Cell"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ccr.2012.05.015","article-title":"A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1\/2","volume":"22","author":"Schlacher","year":"2012","journal-title":"Cancer Cell"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1172\/JCI58928","article-title":"Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR","volume":"122","author":"Schoppy","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/nmeth.1704","article-title":"Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis","volume":"8","author":"Sengupta","year":"2011","journal-title":"Nature Methods"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nsmb1252","article-title":"FANCI is a second monoubiquitinated member of the Fanconi anemia pathway","volume":"14","author":"Sims","year":"2007","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nprot.2012.010","article-title":"Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA","volume":"7","author":"Sirbu","year":"2012","journal-title":"Nature Protocols"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2007.03.009","article-title":"Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair","volume":"129","author":"Smogorzewska","year":"2007","journal-title":"Cell"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/j.dnarep.2009.09.003","article-title":"Polk mutant mice have a spontaneous mutator phenotype","volume":"8","author":"Stancel","year":"2009","journal-title":"DNA Repair"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molcel.2017.09.036","article-title":"Restoration of Replication fork stability in brca1- and brca2-deficient cells by inactivation of SNF2-family fork remodelers","volume":"68","author":"Taglialatela","year":"2017","journal-title":"Molecular Cell"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1182\/blood-2002-01-0278","article-title":"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51","volume":"100","author":"Taniguchi","year":"2002","journal-title":"Blood"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S1097-2765(01)00172-1","article-title":"Positional cloning of a novel Fanconi anemia gene, FANCD2","volume":"7","author":"Timmers","year":"2001","journal-title":"Molecular Cell"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2018.07.011","article-title":"Dual roles of poly(dA:dT) tracts in replication initiation and fork collapse","volume":"174","author":"Tubbs","year":"2018","journal-title":"Cell"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"e31457","DOI":"10.1371\/journal.pone.0031457","article-title":"Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting","volume":"7","author":"Veatch","year":"2012","journal-title":"PLoS ONE"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/biom7010019","article-title":"Common chemical inductors of replication stress: focus on cell\u2010based studies","volume":"7","author":"Vesela","year":"2017","journal-title":"Biomolecules"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.molcel.2017.08.010","article-title":"Replication Fork slowing and reversal upon dna damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity","volume":"67","author":"Vujanovic","year":"2017","journal-title":"Molecular Cell"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1083\/jcb.201702006","article-title":"DNA repair factor RAD18 and DNA polymerase Pol\u03ba confer tolerance of oncogenic DNA replication stress","volume":"216","author":"Yang","year":"2017","journal-title":"The Journal of Cell Biology"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1083\/jcb.201406099","article-title":"Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells","volume":"208","author":"Zellweger","year":"2015","journal-title":"The Journal of Cell Biology"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nature Cell Biology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/41426\/elife-41426-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/41426\/elife-41426-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/41426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:02:18Z","timestamp":1697058138000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/41426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":65,"alternative-id":["10.7554\/eLife.41426"],"URL":"https:\/\/doi.org\/10.7554\/elife.41426","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.41426.023","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.41426.022","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"article-number":"e41426"}}