{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:59:22Z","timestamp":1787032762831,"version":"build-2736575974"},"reference-count":97,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 NS 097343"],"award-info":[{"award-number":["R35 NS 097343"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The activity of neuronal circuits depends on the properties of the constituent neurons and their underlying synaptic and intrinsic currents. We describe the effects of extreme changes in extracellular pH \u2013 from pH 5.5 to 10.4 \u2013 on two central pattern generating networks, the stomatogastric and cardiac ganglia of the crab, Cancer borealis. Given that the physiological properties of ion channels are known to be sensitive to pH within the range tested, it is surprising that these rhythms generally remained robust from pH 6.1 to pH 8.8. The pH sensitivity of these rhythms was highly variable between animals and, unexpectedly, between ganglia. Animal-to-animal variability was likely a consequence of similar network performance arising from variable sets of underlying conductances. Together, these results illustrate the potential difficulty in generalizing the effects of environmental perturbation across circuits, even within the same animal.<\/jats:p>","DOI":"10.7554\/elife.41877","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T08:00:23Z","timestamp":1545984023000},"source":"Crossref","is-referenced-by-count":45,"title":["Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-7124","authenticated-orcid":true,"given":"Jessica A","family":"Haley","sequence":"first","affiliation":[{"name":"Volen Center and Biology Department, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-037X","authenticated-orcid":true,"given":"David","family":"Hampton","sequence":"additional","affiliation":[{"name":"Volen Center and Biology Department, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-5448","authenticated-orcid":true,"given":"Eve","family":"Marder","sequence":"additional","affiliation":[{"name":"Volen Center and Biology Department, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.conb.2017.01.002","article-title":"Functional roles of short-term synaptic plasticity with an emphasis on inhibition","volume":"43","author":"Anwar","year":"2017","journal-title":"Current Opinion in Neurobiology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00424-014-1633-9","article-title":"The role of pH-sensitive TASK channels in central respiratory chemoreception","volume":"467","author":"Bayliss","year":"2015","journal-title":"Pfl\u00fcgers Archiv - 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