{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:19:50Z","timestamp":1772266790623,"version":"3.50.1"},"reference-count":22,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"ALF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Swedish Association of Endocrinologists"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    The\n                    <jats:italic>AIRE<\/jats:italic>\n                    gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with\n                    <jats:italic>AIRE<\/jats:italic>\n                    -deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with\n                    <jats:italic>AIRE<\/jats:italic>\n                    -deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.\n                  <\/jats:p>","DOI":"10.7554\/elife.43578","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T06:00:17Z","timestamp":1561615217000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.43578","source":"Crossref","is-referenced-by-count":6,"title":["Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-9540","authenticated-orcid":true,"given":"Nils","family":"Landegren","sequence":"first","affiliation":[{"name":"Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey B","family":"Rosen","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Freyhult","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, National Bioinformatics Infrastructure, Uppsala, Sweden"},{"name":"Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-3312","authenticated-orcid":true,"given":"Daniel","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Fall","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Molecular Epidemiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Lund University, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Program in Medical and Population Genetics, Broad Institute of Harvard, Massachusetts Institute of Technology, Cambridge, United States"},{"name":"Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-7768","authenticated-orcid":true,"given":"Elise M 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