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Here we report that, in larval zebrafish, primarily serotonergic neurons of the ventromedial caudal hypothalamus (cH) become increasingly active during food deprivation, whereas activity in the lateral hypothalamus (LH) is reduced. Exposure to food sensory and consummatory cues reverses the activity patterns of these two nuclei, consistent with their representation of opposing internal hunger states. Baseline activity is restored as food-deprived animals return to satiety via voracious feeding. The antagonistic relationship and functional importance of cH and LH activity patterns were confirmed by targeted stimulation and ablation of cH neurons. Collectively, the data allow us to propose a model in which these hypothalamic nuclei regulate different phases of hunger and satiety and coordinate energy balance via antagonistic control of distinct behavioral outputs.<\/jats:p>","DOI":"10.7554\/elife.43775","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T09:00:19Z","timestamp":1571302819000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.43775","source":"Crossref","is-referenced-by-count":86,"title":["A bidirectional network for appetite control in larval zebrafish"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-550X","authenticated-orcid":true,"given":"Caroline Lei","family":"Wee","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, Harvard University","place":["Cambridge, United States"]},{"name":"Program in Neuroscience, Harvard University","place":["Boston, United 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