{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:09:20Z","timestamp":1753895360965,"version":"3.41.2"},"reference-count":11,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.<\/jats:p>","DOI":"10.7554\/elife.43928","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T10:02:53Z","timestamp":1548842573000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.43928","source":"Crossref","is-referenced-by-count":5,"title":["Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-8921","authenticated-orcid":true,"given":"David J","family":"Goldhamer","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-5799","authenticated-orcid":true,"given":"John B","family":"Lees-Shepard","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0925-4773(00)00321-X","article-title":"Platelet-derived growth factor A modulates limb chondrogenesis both in vivo and in vitro","volume":"94","author":"Ataliotis","year":"2000","journal-title":"Mechanisms of Development"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1002\/jbmr.1637","article-title":"An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva","volume":"27","author":"Chakkalakal","year":"2012","journal-title":"Journal of Bone and Mineral Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1002\/jbmr.2820","article-title":"Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1(R206H) Fibrodysplasia ossificans progressiva (FOP) Mutation","volume":"31","author":"Chakkalakal","year":"2016","journal-title":"Journal of Bone and Mineral Research"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1128\/MCB.23.11.4013-4025.2003","article-title":"Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms","volume":"23","author":"Hamilton","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1242\/dmm.010280","article-title":"Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis","volume":"5","author":"Kaplan","year":"2012","journal-title":"Disease Models & Mechanisms"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40814","article-title":"Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity","volume":"7","author":"Lees-Shepard","year":"2018","journal-title":"eLife"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02872-2","article-title":"Activin-dependent signaling in fibro\/adipogenic progenitors causes fibrodysplasia ossificans progressiva","volume":"9","author":"Lees-Shepard","year":"2018","journal-title":"Nature Communications"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bone.2018.01.029","article-title":"Stem cells and heterotopic ossification: Lessons from animal models","volume":"109","author":"Lees-Shepard","year":"2018","journal-title":"Bone"},{"key":"bib9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.115.4.1045","article-title":"Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo","volume":"115","author":"Orr-Urtreger","year":"1992","journal-title":"Development"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43173","article-title":"Comment on 'Palovarotene reducesheterotopic ossification in juvenile FOP mice but exhibits pronounced skeletaltoxicity'","volume":"8","author":"Pacifici","year":"2019","journal-title":"eLife"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/dev.115.1.123","article-title":"Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis","volume":"115","author":"Schatteman","year":"1992","journal-title":"Development"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/43928\/elife-43928-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/43928\/elife-43928-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/43928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:54:37Z","timestamp":1697072077000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/43928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":11,"alternative-id":["10.7554\/eLife.43928"],"URL":"https:\/\/doi.org\/10.7554\/elife.43928","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"type":"electronic","value":"2050-084X"}],"subject":[],"published":{"date-parts":[[2019,1,30]]},"article-number":"e43928"}}