{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:33:36Z","timestamp":1793140416534,"version":"4.5.0"},"reference-count":80,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["335605"],"award-info":[{"award-number":["335605"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["818858"],"award-info":[{"award-number":["818858"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2015289"],"award-info":[{"award-number":["2015289"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001658","name":"Minerva Foundation","doi-asserted-by":"publisher","award":["712610"],"award-info":[{"award-number":["712610"]}],"id":[{"id":"10.13039\/501100001658","id-type":"DOI","asserted-by":"publisher"}]},{"name":"H and M Kimmel Institute for Stem Cell Research, the Estate of Emile Mimran","award":["SABRA program"],"award-info":[{"award-number":["SABRA program"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL081674"],"award-info":[{"award-number":["R01 HL081674"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL131319"],"award-info":[{"award-number":["R01 HL131319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 136182"],"award-info":[{"award-number":["R01 136182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-HL128503"],"award-info":[{"award-number":["RO1-HL128503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003194","name":"New York Stem Cell Foundation","doi-asserted-by":"publisher","award":["Robertson Investigator"],"award-info":[{"award-number":["Robertson Investigator"]}],"id":[{"id":"10.13039\/100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["394046768 \u2013 SFB 1366"],"award-info":[{"award-number":["394046768 \u2013 SFB 1366"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to promote healing of the heart. Yet, the mechanisms governing cardiac lymphatic growth remain unclear. Here, we identify two distinct lymphatic populations in the hearts of zebrafish and mouse, one that forms through sprouting lymphangiogenesis, and the other by coalescence of isolated lymphatic cells. By tracing the development of each subset, we reveal diverse cellular origins and differential response to signaling cues. Finally, we show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lymphatics display severely impaired regeneration capabilities. Overall, our results provide novel insight into the mechanisms underlying lymphatic formation during development and regeneration, opening new avenues for interventions targeting specific lymphatic populations.<\/jats:p>","DOI":"10.7554\/elife.44153","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T08:00:14Z","timestamp":1573200014000},"source":"Crossref","is-referenced-by-count":111,"title":["Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration"],"prefix":"10.7554","volume":"8","author":[{"given":"Dana","family":"Gancz","sequence":"first","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C","family":"Raftrey","sequence":"additional","affiliation":[{"name":"Department of Biology, Stanford University, Stanford, United States"},{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-3008","authenticated-orcid":true,"given":"Gal","family":"Perlmoter","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5903-7463","authenticated-orcid":true,"given":"Rub\u00e9n","family":"Mar\u00edn-Juez","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Semo","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-2889","authenticated-orcid":true,"given":"Ryota L","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Karra","sequence":"additional","affiliation":[{"name":"Regeneration Next, Duke University, Durham, United States"},{"name":"Department of Medicine, Duke University School of Medicine, Durham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Raviv","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noga","family":"Moshe","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoseph","family":"Addadi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-236X","authenticated-orcid":true,"given":"Ofra","family":"Golani","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D","family":"Poss","sequence":"additional","affiliation":[{"name":"Regeneration Next, Duke University, Durham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Red-Horse","sequence":"additional","affiliation":[{"name":"Department of Biology, Stanford University, Stanford, United States"},{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-0026","authenticated-orcid":true,"given":"Didier YR","family":"Stainier","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-7150","authenticated-orcid":true,"given":"Karina","family":"Yaniv","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cmet.2015.06.013","article-title":"Lymphatic vessels at the heart of the matter","volume":"22","author":"Angeli","year":"2015","journal-title":"Cell Metabolism"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and plasticity of meningeal lymphatic vessels","volume":"214","author":"Antila","year":"2017","journal-title":"The Journal of Experimental Medicine"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1242\/dev.106591","article-title":"Vegfd can compensate for loss of vegfc in zebrafish facial lymphatic sprouting","volume":"141","author":"Astin","year":"2014","journal-title":"Development"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/nm.2759","article-title":"ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1","volume":"18","author":"Avraham-Davidi","year":"2012","journal-title":"Nature Medicine"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1161\/01.RES.0000065621.69843.49","article-title":"Interstitial flow as a guide for lymphangiogenesis","volume":"92","author":"Boardman","year":"2003","journal-title":"Circulation Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/dvdy.24670","article-title":"CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart","volume":"247","author":"Bonet","year":"2018","journal-title":"Developmental Dynamics"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.111.250738","article-title":"CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo","volume":"109","author":"Bos","year":"2011","journal-title":"Circulation Research"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1242\/dev.146969","article-title":"Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development","volume":"144","author":"Bower","year":"2017","journal-title":"Development"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nn.4558","article-title":"Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish","volume":"20","author":"Bower","year":"2017","journal-title":"Nature Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41569-018-0087-8","article-title":"Cardiac lymphatics in health and disease","volume":"16","author":"Brakenhielm","year":"2019","journal-title":"Nature Reviews Cardiology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1242\/dev.059881","article-title":"Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling","volume":"138","author":"Bussmann","year":"2011","journal-title":"Development"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.devcel.2012.01.011","article-title":"Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature","volume":"22","author":"Cha","year":"2012","journal-title":"Developmental Cell"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1172\/JCI77483","article-title":"VEGF-C and aortic cardiomyocytes guide coronary artery stem development","volume":"124","author":"Chen","year":"2014","journal-title":"Journal of Clinical Investigation"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"4500","DOI":"10.1242\/dev.113639","article-title":"The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis","volume":"141","author":"Chen","year":"2014","journal-title":"Development"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.cell.2018.12.023","article-title":"A unique collateral artery development program promotes neonatal heart regeneration","volume":"176","author":"Das","year":"2019","journal-title":"Cell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature14435","article-title":"A new heart for a new head in vertebrate cardiopharyngeal evolution","volume":"520","author":"Diogo","year":"2015","journal-title":"Nature"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1242\/dev.093351","article-title":"Notch controls retinal blood vessel maturation and quiescence","volume":"140","author":"Ehling","year":"2013","journal-title":"Development"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847079","article-title":"Zebrafish facial lymphatics develop through sequential addition of venous and non\u2010venous progenitors","volume":"20","author":"Eng","year":"2019","journal-title":"EMBO Reports"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ydbio.2005.02.002","article-title":"Insertion of cre into the Pax3 locus creates a new allele of splotch and identifies unexpected Pax3 derivatives","volume":"280","author":"Engleka","year":"2005","journal-title":"Developmental Biology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/ar.22912","article-title":"Cardiac mouse lymphatics: developmental and anatomical update","volume":"297","author":"Flaht-Zabost","year":"2014","journal-title":"The Anatomical Record"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1242\/dev.058776","article-title":"Assembly and patterning of the vascular network of the vertebrate hindbrain","volume":"138","author":"Fujita","year":"2011","journal-title":"Development"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1161\/ATVBAHA.116.308119","article-title":"Autotaxin-Lysophosphatidic acid Axis acts downstream of apoprotein B lipoproteins in endothelial cells","volume":"36","author":"Gibbs-Bar","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1242\/dev.060897","article-title":"Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish","volume":"138","author":"Gonz\u00e1lez-Rosa","year":"2011","journal-title":"Development"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/reg2.83","article-title":"Zebrafish heart regeneration: 15 years of discoveries","volume":"4","author":"Gonz\u00e1lez-Rosa","year":"2017","journal-title":"Regeneration"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An injury-responsive gata4 program shapes the zebrafish cardiac ventricle","volume":"23","author":"Gupta","year":"2013","journal-title":"Current Biology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.devcel.2015.04.001","article-title":"Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish","volume":"33","author":"Harrison","year":"2015","journal-title":"Developmental Cell"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122665","article-title":"Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury","volume":"10","author":"Hein","year":"2015","journal-title":"PLOS ONE"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.115.020143","article-title":"Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction","volume":"133","author":"Henri","year":"2016","journal-title":"Circulation"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/ng.321","article-title":"Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting","volume":"41","author":"Hogan","year":"2009","journal-title":"Nature Genetics"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1365-2559.2007.02785.x","article-title":"Lymphangiogenesis in myocardial remodelling after infarction","volume":"51","author":"Ishikawa","year":"2007","journal-title":"Histopathology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1006\/dbio.2000.9995","article-title":"The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development","volume":"230","author":"Isogai","year":"2001","journal-title":"Developmental Biology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1242\/dev.079756","article-title":"Migration of cardiomyocytes is essential for heart regeneration in zebrafish","volume":"139","author":"Itou","year":"2012","journal-title":"Development"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.devcel.2015.03.026","article-title":"The CXCL12\/CXCR4 Axis plays a critical role in coronary artery development","volume":"33","author":"Ivins","year":"2015","journal-title":"Developmental Cell"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04982-1","article-title":"Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1","volume":"7","author":"Jha","year":"2017","journal-title":"Scientific Reports"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1242\/dev.02087","article-title":"Cellular and molecular analyses of vascular tube and lumen formation in zebrafish","volume":"132","author":"Jin","year":"2005","journal-title":"Development"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1161\/01.CIR.33.1.137","article-title":"Lymphatics of the heart","volume":"33","author":"Johnson","year":"1966","journal-title":"Circulation"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1242\/dev.145755","article-title":"Development of the larval lymphatic system in zebrafish","volume":"144","author":"Jung","year":"2017","journal-title":"Development"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"8805","DOI":"10.1073\/pnas.1722594115","article-title":"Vegfaa instructs cardiac muscle Hyperplasia in adult zebrafish","volume":"115","author":"Karra","year":"2018","journal-title":"PNAS"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature14483","article-title":"Cardiac lymphatics are heterogeneous in origin and respond to injury","volume":"522","author":"Klotz","year":"2015","journal-title":"Nature"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.devcel.2014.11.018","article-title":"Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish","volume":"32","author":"Kok","year":"2015","journal-title":"Developmental Cell"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mod.2010.09.003","article-title":"Lymphatic ontogeny and effect of hypoplasia in developing lung","volume":"128","author":"Kulkarni","year":"2011","journal-title":"Mechanisms of Development"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1242\/dev.100495","article-title":"Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis","volume":"141","author":"Le Guen","year":"2014","journal-title":"Development"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7020","article-title":"Genetic targeting of sprouting angiogenesis using Apln-CreER","volume":"6","author":"Liu","year":"2015","journal-title":"Nature Communications"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.devcel.2014.11.002","article-title":"The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine","volume":"31","author":"Mahadevan","year":"2014","journal-title":"Developmental Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"11237","DOI":"10.1073\/pnas.1605431113","article-title":"Fast revascularization of the injured area is essential to support zebrafish heart regeneration","volume":"113","author":"Mar\u00edn-Juez","year":"2016","journal-title":"PNAS"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1161\/CIRCRESAHA.116.306170","article-title":"Nonvenous origin of dermal lymphatic vasculature","volume":"116","author":"Martinez-Corral","year":"2015","journal-title":"Circulation Research"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ydbio.2019.05.002","article-title":"Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development","volume":"452","author":"Maruyama","year":"2019","journal-title":"Developmental Biology"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20253","article-title":"Radial Glia regulate vascular patterning around the developing spinal cord","volume":"5","author":"Matsuoka","year":"2016","journal-title":"eLife"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2569","article-title":"Haemogenic endocardium contributes to transient definitive haematopoiesis","volume":"4","author":"Nakano","year":"2013","journal-title":"Nature Communications"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature14425","article-title":"Lymphatic vessels arise from specialized angioblasts within a venous niche","volume":"522","author":"Nicenboim","year":"2015","journal-title":"Nature"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/ca.22638","article-title":"Anatomy and development of the cardiac lymphatic vasculature: its role in injury and disease","volume":"29","author":"Norman","year":"2016","journal-title":"Clinical Anatomy"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1242\/dev.077701","article-title":"lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish","volume":"139","author":"Okuda","year":"2012","journal-title":"Development"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/S0002-9440(10)65021-3","article-title":"Vascular endothelial growth factor receptor-3 in Lymphangiogenesis in wound healing","volume":"156","author":"Paavonen","year":"2000","journal-title":"The American Journal of Pathology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1002\/dvdy.22113","article-title":"Normal table of postembryonic zebrafish development: staging by externally visible anatomy of the living fish","volume":"238","author":"Parichy","year":"2009","journal-title":"Developmental Dynamics"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1242\/dev.160184","article-title":"A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development","volume":"145","author":"Pichol-Thievend","year":"2018","journal-title":"Development"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41586-018-0552-x","article-title":"Erythro-myeloid progenitors contribute endothelial cells to blood vessels","volume":"562","author":"Plein","year":"2018","journal-title":"Nature"},{"key":"bib58","doi-asserted-by":"publisher","DOI":"10.3791\/1645","article-title":"Retro-orbital injection in adult zebrafish","volume":"7","author":"Pugach","year":"2009","journal-title":"Journal of Visualized Experiments"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nature08873","article-title":"Coronary arteries form by developmental reprogramming of venous cells","volume":"464","author":"Red-Horse","year":"2010","journal-title":"Nature"},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-018-0059-y","article-title":"Parallels between vertebrate cardiac and cutaneous wound healing and regeneration","volume":"3","author":"Richardson","year":"2018","journal-title":"Npj Regenerative Medicine"},{"key":"bib61","volume-title":"Nova Exervitatio Anatomia Exhibens Ductus Hepatico Aquosos Et Vasa Glandularum Serosa, Nune Primum Inventa, Aenesisque \ufb01guris Delineata","author":"Rudbeck","year":"1653"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"H1402","DOI":"10.1152\/ajpheart.00038.2006","article-title":"Characterization of lymphangiogenesis in a model of adult skin regeneration","volume":"291","author":"Rutkowski","year":"2006","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1242\/dev.132431","article-title":"Development of the lymphatic system: new questions and paradigms","volume":"143","author":"Semo","year":"2016","journal-title":"Development"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1101\/gad.1813509","article-title":"Chemokine signaling guides regional patterning of the first embryonic artery","volume":"23","author":"Siekmann","year":"2009","journal-title":"Genes & Development"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.celrep.2015.02.026","article-title":"cKit lineage hemogenic Endothelium-Derived cells contribute to mesenteric lymphatic vessels","volume":"10","author":"Stanczuk","year":"2015","journal-title":"Cell Reports"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.devcel.2019.04.034","article-title":"Paraxial mesoderm is the major source of lymphatic endothelium","volume":"50","author":"Stone","year":"2019","journal-title":"Developmental Cell"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41586-018-0288-7","article-title":"Single-cell analysis of early progenitor cells that build coronary arteries","volume":"559","author":"Su","year":"2018","journal-title":"Nature"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006596","article-title":"Cardiac hypertrophy involves both myocyte hypertrophy and Hyperplasia in anemic zebrafish","volume":"4","author":"Sun","year":"2009","journal-title":"PLOS ONE"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1093\/cvr\/cvw175","article-title":"Heterogeneity in the lymphatic vascular system and its origin","volume":"111","author":"Ulvmar","year":"2016","journal-title":"Cardiovascular Research"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1242\/dev.105031","article-title":"Divergence of zebrafish and mouse lymphatic cell fate specification pathways","volume":"141","author":"van Impel","year":"2014","journal-title":"Development"},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25932","article-title":"Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development","volume":"6","author":"van Lessen","year":"2017","journal-title":"eLife"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1172\/JCI97192","article-title":"The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction","volume":"128","author":"Vieira","year":"2018","journal-title":"Journal of Clinical Investigation"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1242\/dev.084152","article-title":"A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development","volume":"140","author":"Villefranc","year":"2013","journal-title":"Development"},{"key":"bib74","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-019-0079-2","article-title":"Vegfc\/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context","volume":"4","author":"Vivien","year":"2019","journal-title":"Npj Regenerative Medicine"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.tem.2016.12.002","article-title":"Cardiac lymphatics - A new avenue for therapeutics?","volume":"28","author":"Vuorio","year":"2017","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","article-title":"Transparent adult zebrafish as a tool for in vivo transplantation analysis","volume":"2","author":"White","year":"2008","journal-title":"Cell Stem Cell"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.cell.2012.10.023","article-title":"Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling","volume":"151","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nm1427","article-title":"Live imaging of lymphatic development in the zebrafish","volume":"12","author":"Yaniv","year":"2006","journal-title":"Nature Medicine"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20994","article-title":"Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta","volume":"6","author":"Zamir","year":"2017","journal-title":"eLife"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027385","article-title":"A computational tool for quantitative analysis of vascular networks","volume":"6","author":"Zudaire","year":"2011","journal-title":"PLOS ONE"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44153\/elife-44153-v3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44153\/elife-44153-v3.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/44153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:54:55Z","timestamp":1697057695000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/44153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":80,"alternative-id":["10.7554\/eLife.44153"],"URL":"https:\/\/doi.org\/10.7554\/elife.44153","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.44153.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.44153.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"article-number":"e44153"}}