{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:35:51Z","timestamp":1792632951720,"version":"4.5.0"},"reference-count":139,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31NS105461"],"award-info":[{"award-number":["F31NS105461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","award":["Huck Graduate Enrichment Grant"],"award-info":[{"award-number":["Huck Graduate Enrichment Grant"]}],"id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET1705854"],"award-info":[{"award-number":["CBET1705854"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000872","name":"McKnight Endowment Fund for Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS078168"],"award-info":[{"award-number":["R01NS078168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD078233"],"award-info":[{"award-number":["P01HD078233"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, we characterized the anatomy and physiological function of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in intracranial pressure (ICP), consistent with an alteration in the pattern of CSF drainage or production. Our results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases.<\/jats:p>","DOI":"10.7554\/elife.44278","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T08:00:23Z","timestamp":1557216023000},"source":"Crossref","is-referenced-by-count":143,"title":["Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-5938","authenticated-orcid":true,"given":"Jordan N","family":"Norwood","sequence":"first","affiliation":[{"name":"Cellular and Developmental Biology Graduate Program, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-813X","authenticated-orcid":true,"given":"Qingguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Card","sequence":"additional","affiliation":[{"name":"Department of Physics, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Craine","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Anthropology, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-7378","authenticated-orcid":true,"given":"Patrick J","family":"Drew","sequence":"additional","affiliation":[{"name":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, United States"},{"name":"Department of Biomedical Engineering, Pennsylvania State University, University Park, United States"},{"name":"Department of Neurosurgery, Pennsylvania State University, University Park, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1679\/aohc.69.1","article-title":"Immunolocalization of water channel aquaporins in the nasal olfactory mucosa","volume":"69","author":"Ablimit","year":"2006","journal-title":"Archives of Histology and Cytology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1002\/alr.21829","article-title":"Nitrogen dioxide pollution exposure is associated with olfactory dysfunction in older U.S. adults","volume":"6","author":"Adams","year":"2016","journal-title":"International Forum of Allergy & Rhinology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1289\/EHP136","article-title":"Effects of ambient air pollution exposure on olfaction: a review","volume":"124","author":"Ajmani","year":"2016","journal-title":"Environmental Health Perspectives"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s002239900108","article-title":"Immunolocalization of the cation-independent mannose 6-phosphate receptor and cathepsin B in the enamel organ and alveolar bone of the rat incisor","volume":"59","author":"Al Kawas","year":"1996","journal-title":"Calcified Tissue International"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3171\/jns.1998.89.2.0275","article-title":"Age dependency of resistance to cerebrospinal fluid outflow","volume":"89","author":"Albeck","year":"1998","journal-title":"Journal of Neurosurgery"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and plasticity of meningeal lymphatic vessels","volume":"214","author":"Antila","year":"2017","journal-title":"The Journal of Experimental Medicine"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"The Journal of Experimental Medicine"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cne.10182","article-title":"Sublaminar organization of the mouse olfactory bulb nerve layer","volume":"446","author":"Au","year":"2002","journal-title":"The Journal of Comparative Neurology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/jmor.1051420104","article-title":"Cribriform plate of ethmoid, olfactory bulb and olfactory acuity in forty species of bats","volume":"142","author":"Bhatnagar","year":"1974","journal-title":"Journal of Morphology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1002\/ar.23032","article-title":"Quantifying the cribriform plate: influences of allometry, function, and phylogeny in carnivora","volume":"297","author":"Bird","year":"2014","journal-title":"The Anatomical Record"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.0100","article-title":"Olfaction written in bone: cribriform plate size parallels olfactory receptor gene repertoires in mammalia","volume":"285","author":"Bird","year":"2018","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1038\/sj.jcbfm.9600306","article-title":"Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice","volume":"26","author":"Bloch","year":"2006","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1365-2990.1996.tb01111.x","article-title":"Drainage of CSF through lymphatic pathways and arachnoid villi in sheep: measurement of 125I-albumin clearance","volume":"22","author":"Boulton","year":"1996","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"F329","DOI":"10.1152\/ajprenal.1981.240.4.F329","article-title":"Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit","volume":"240","author":"Bradbury","year":"1981","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1113\/jphysiol.1980.sp013129","article-title":"The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour","volume":"299","author":"Bradbury","year":"1980","journal-title":"The Journal of Physiology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1113\/jphysiol.1983.sp014731","article-title":"Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit","volume":"339","author":"Bradbury","year":"1983","journal-title":"The Journal of Physiology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0092-8674(91)90418-X","article-title":"A novel multigene family may encode odorant receptors: a molecular basis for odor recognition","volume":"65","author":"Buck","year":"1991","journal-title":"Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"9858","DOI":"10.1073\/pnas.93.18.9858","article-title":"Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons","volume":"93","author":"Buiakova","year":"1996","journal-title":"PNAS"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/jemt.1070240302","article-title":"Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb","volume":"24","author":"Burd","year":"1993","journal-title":"Microscopy Research and Technique"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1080\/01926230490520232","article-title":"Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution","volume":"32","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2004","journal-title":"Toxicologic Pathology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3233\/JAD-2011-110722","article-title":"Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults","volume":"28","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2012","journal-title":"Journal of Alzheimer's Disease"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.envres.2016.06.026","article-title":"Interactive and additive influences of gender, BMI and apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City","volume":"150","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2016","journal-title":"Environmental Research"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.envres.2015.12.031","article-title":"Prefrontal white matter pathology in air pollution exposed Mexico city young urbanites and their potential impact on neurovascular unit dysfunction and the development of alzheimer's disease","volume":"146","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2016","journal-title":"Environmental Research"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S0140-6736(16)32399-6","article-title":"Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study","volume":"389","author":"Chen","year":"2017","journal-title":"The Lancet"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.envint.2017.08.020","article-title":"Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study","volume":"108","author":"Chen","year":"2017","journal-title":"Environment International"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrm1368","article-title":"Shaping the nuclear action of NF-kappaB","volume":"5","author":"Chen","year":"2004","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1289\/EHP134","article-title":"Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain","volume":"124","author":"Cheng","year":"2016","journal-title":"Environmental Health Perspectives"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0167-5699(92)90027-5","article-title":"Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view","volume":"13","author":"Cserr","year":"1992","journal-title":"Immunology Today"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1750-3639.1992.tb00703.x","article-title":"Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance","volume":"2","author":"Cserr","year":"1992","journal-title":"Brain Pathology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-3-642-76894-1_9","volume-title":"Physiology and Pharmacology of the Blood-Brain Barrier","volume":"103","author":"Cserr","year":"1992"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1088\/0967-3334\/25\/5\/R01","article-title":"Cerebrospinal fluid dynamics","volume":"25","author":"Czosnyka","year":"2004","journal-title":"Physiological Measurement"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1152\/physrev.00004.2013","article-title":"Cerebrospinal fluid secretion by the choroid plexus","volume":"93","author":"Damkier","year":"2013","journal-title":"Physiological Reviews"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2967\/jnumed.116.187211","article-title":"Cerebrospinal fluid clearance in alzheimer disease measured with dynamic PET","volume":"58","author":"de Leon","year":"2017","journal-title":"Journal of Nuclear Medicine"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature19356","article-title":"High-throughput discovery of novel developmental phenotypes","volume":"537","author":"Dickinson","year":"2016","journal-title":"Nature"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0006-8993(72)90655-5","article-title":"Localization within the lower brainstem of a receptive area mediating the pressor response to increased intracranial pressure (the cushing response)","volume":"47","author":"Doba","year":"1972","journal-title":"Brain Research"},{"key":"bib36","first-page":"547","article-title":"Neurotoxic exposure and olfactory impairment","volume":"1","author":"Doty","year":"2001","journal-title":"Clinics in Occupational and Environmental Medicine"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyg.2014.00020","article-title":"The influences of age on olfaction: a review","volume":"5","author":"Doty","year":"2014","journal-title":"Frontiers in Psychology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nmeth.1530","article-title":"Chronic optical access through a polished and reinforced thinned skull","volume":"7","author":"Drew","year":"2010","journal-title":"Nature Methods"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.14440\/jbm.2014.36","article-title":"Advanced methods of microscope control using \u03bcmanager software","volume":"1","author":"Edelstein","year":"2014","journal-title":"\u00a0Journal of Biological\u00a0Methods"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0014-4886(78)90063-8","article-title":"Autonomic vascular innervation and vasomotor reactivity in the choroid plexus","volume":"62","author":"Edvinsson","year":"1978","journal-title":"Experimental Neurology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jneumeth.2011.01.008","article-title":"OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro","volume":"196","author":"Ekberg","year":"2011","journal-title":"Journal of Neuroscience Methods"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3171\/jns.1986.64.3.0466","article-title":"Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit","volume":"64","author":"Erlich","year":"1986","journal-title":"Journal of Neurosurgery"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3233\/JAD-130659","article-title":"Disruption of cerebrospinal fluid flow through the olfactory system may contribute to Alzheimer's disease pathogenesis","volume":"41","author":"Ethell","year":"2014","journal-title":"Journal of Alzheimer's Disease"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.cell.2004.05.011","article-title":"A contextual model for axonal sorting into glomeruli in the mouse olfactory system","volume":"117","author":"Feinstein","year":"2004","journal-title":"Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1152\/ajplegacy.1969.216.3.675","article-title":"Equilibrium and kinetic properties of the evans blue-albumin system","volume":"216","author":"Freedman","year":"1969","journal-title":"American Journal of Physiology-Legacy Content"},{"key":"bib46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/clinchem\/20.5.571","article-title":"Measurement of IgG and albumin content of cerebrospinal fluid, and its interpretation","volume":"20","author":"Ganrot","year":"1974","journal-title":"Clinical Chemistry"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.neuroimage.2016.11.069","article-title":"Time to wake up: studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal","volume":"153","author":"Gao","year":"2017","journal-title":"NeuroImage"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/jcbfm.2014.67","article-title":"Determination of vessel cross-sectional area by thresholding in radon space","volume":"34","author":"Gao","year":"2014","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1523\/JNEUROSCI.3665-15.2016","article-title":"Effects of voluntary locomotion and calcitonin Gene-Related peptide on the dynamics of single dural vessels in awake mice","volume":"36","author":"Gao","year":"2016","journal-title":"The Journal of Neuroscience"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"R1049","DOI":"10.1152\/ajpregu.00183.2018","article-title":"Intracranial pressure influences the level of sympathetic tone","volume":"315","author":"Guild","year":"2018","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jim.2007.11.012","article-title":"Lymph node mapping in the mouse","volume":"332","author":"Harrell","year":"2008","journal-title":"Journal of Immunological Methods"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.2.4.041402","article-title":"Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice","volume":"2","author":"Hartmann","year":"2015","journal-title":"Neurophotonics"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1001\/archneur.1970.00480270038006","article-title":"Localization of regions mediating the cushing response in CNS of cat","volume":"23","author":"Hoff","year":"1970","journal-title":"Archives of Neurology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.ajpath.2012.05.021","article-title":"Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats","volume":"181","author":"Hubbs","year":"2012","journal-title":"The American Journal of Pathology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"10975","DOI":"10.1523\/JNEUROSCI.1369-14.2014","article-title":"Neurovascular coupling and decoupling in the cortex during voluntary locomotion","volume":"34","author":"Huo","year":"2014","journal-title":"Journal of Neuroscience"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.neuroimage.2014.10.030","article-title":"Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion","volume":"105","author":"Huo","year":"2015","journal-title":"NeuroImage"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Science Translational Medicine"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2016.00475","article-title":"Environmental Toxicants-Induced immune responses in the olfactory mucosa","volume":"7","author":"Imamura","year":"2016","journal-title":"Frontiers in Immunology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.1523\/JNEUROSCI.3359-17.2018","article-title":"Cerebrospinal Fluid-Contacting neurons sense pH changes and motion in the hypothalamus","volume":"38","author":"Jalalvand","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00441-005-1120-x","article-title":"Aquaporin-1 in the choroid plexuses of developing mammalian brain","volume":"322","author":"Johansson","year":"2005","journal-title":"Cell and Tissue Research"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-1-2","article-title":"Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species","volume":"1","author":"Johnston","year":"2004","journal-title":"Cerebrospinal Fluid Research"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1365-2990.2005.00679.x","article-title":"Subarachnoid injection of microfil reveals connections between cerebrospinal fluid and nasal lymphatics in the non-human primate","volume":"31","author":"Johnston","year":"2005","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/0014-4886(85)90049-4","article-title":"Cerebrospinal fluid pressure and resistance to absorption during development in normal and hydrocephalic mutant mice","volume":"90","author":"Jones","year":"1985","journal-title":"Experimental Neurology"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/(SICI)1097-0185(199807)251:3<326::AID-AR7>3.0.CO;2-T","article-title":"Age-related size reduction of foramina in the cribriform plate","volume":"251","author":"Kalmey","year":"1998","journal-title":"The Anatomical Record"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/nn.3447","article-title":"SeeDB : a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction","volume":"16","author":"Ke","year":"2013","journal-title":"Nature Neuroscience"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1365-2990.1993.tb00476.x","article-title":"CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. anatomy, histology and immunological significance","volume":"19","author":"Kida","year":"1993","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF02337824","article-title":"The arterial supply of the clavicle","volume":"11","author":"Knudsen","year":"1989","journal-title":"Surgical and Radiologic Anatomy"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00429-006-0085-1","article-title":"Development of cerebrospinal fluid absorption sites in the pig and rat: connections between the subarachnoid space and lymphatic vessels in the olfactory turbinates","volume":"211","author":"Koh","year":"2006","journal-title":"Anatomy and Embryology"},{"key":"bib69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/3-211-32318-X_65","article-title":"Age-dependence of cerebrospinal parameters","volume":"95","author":"K\u00f6nig","year":"2005","journal-title":"Acta Neurochirurgica. Supplement"},{"key":"bib70","first-page":"1","article-title":"\u201cIntracranial pressure: cerebrospinal fluid dynamics and pressure-volume relations,\u201d","volume":"111","author":"Kosteljanetz","year":"1987","journal-title":"Acta Neurologica Scandinavica. Supplementum"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.arr.2003.10.003","article-title":"Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders","volume":"3","author":"Kov\u00e1cs","year":"2004","journal-title":"Ageing Research Reviews"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jconrel.2018.08.006","article-title":"Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: distribution, dose-response, and mechanisms of delivery","volume":"286","author":"Kumar","year":"2018","journal-title":"Journal of Controlled Release"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrneurol.2016.13","article-title":"Ultrasound treatment of neurological diseases--current and emerging applications","volume":"12","author":"Leinenga","year":"2016","journal-title":"Nature Reviews Neurology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/nprot.2008.172","article-title":"Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI","volume":"3","author":"Li","year":"2008","journal-title":"Nature Protocols"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1126\/science.663649","article-title":"Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus","volume":"201","author":"Lindvall","year":"1978","journal-title":"Science"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Advanced Drug Delivery Reviews"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01484-6","article-title":"Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice","volume":"8","author":"Ma","year":"2017","journal-title":"Nature Communications"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00401-018-1916-x","article-title":"Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain","volume":"137","author":"Ma","year":"2019","journal-title":"Acta Neuropathologica"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1080\/01616412.2018.1446282","article-title":"Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes","volume":"40","author":"Maloveska","year":"2018","journal-title":"Neurological Research"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3171\/jns.1975.43.5.0523","article-title":"Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system","volume":"43","author":"Marmarou","year":"1975","journal-title":"Journal of Neurosurgery"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/jcbfm.2009.15","article-title":"Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation","volume":"29","author":"Marques","year":"2009","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1212\/WNL.40.3_Part_1.500","article-title":"Cerebrospinal fluid production is reduced in healthy aging","volume":"40","author":"May","year":"1990","journal-title":"Neurology"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/chemse\/bjg053","article-title":"Does intranasal application of zinc sulfate produce anosmia in the mouse? an olfactometric and anatomical study","volume":"28","author":"McBride","year":"2003","journal-title":"Chemical Senses"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3171\/jns.1983.59.3.0369","article-title":"Recent research into the nature of cerebrospinal fluid formation and absorption","volume":"59","author":"McComb","year":"1983","journal-title":"Journal of Neurosurgery"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"R1593","DOI":"10.1152\/ajpregu.00695.2001","article-title":"Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure","volume":"282","author":"Mollanji","year":"2002","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1001\/jama.288.18.2307","article-title":"Prevalence of olfactory impairment in older adults","volume":"288","author":"Murphy","year":"2002","journal-title":"Jama"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1152\/physrev.00011.2013","article-title":"Physiological roles of aquaporin-4 in brain","volume":"93","author":"Nagelhus","year":"2013","journal-title":"Physiological Reviews"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"R1383","DOI":"10.1152\/ajpregu.00235.2006","article-title":"Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats","volume":"291","author":"Nagra","year":"2006","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1741-4520.2002.tb00851.x","article-title":"Hydrocephalus manifestation in the genetic polydactyly\/ arhinencephaly mouse (Pdn\/Pdn)","volume":"42","author":"Naruse","year":"2002","journal-title":"Congenital Anomalies"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"The Journal of Neuroscience"},{"key":"bib93","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1096\/fj.04-1711fje","article-title":"Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1","volume":"19","author":"Oshio","year":"2005","journal-title":"The FASEB Journal"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"R869","DOI":"10.1152\/ajpregu.00173.2002","article-title":"Does neonatal cerebrospinal fluid absorption occur via arachnoid projections or extracranial lymphatics?","volume":"283","author":"Papaiconomou","year":"2002","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1084\/jem.20091619","article-title":"Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning","volume":"207","author":"Pham","year":"2010","journal-title":"The Journal of Experimental Medicine"},{"key":"bib96","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1098\/rspb.2004.2993","article-title":"Scaling of mammalian ethmoid bones can predict olfactory organ size and performance","volume":"272","author":"Pihlstr\u00f6m","year":"2005","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"bib97","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1113\/JP275105","article-title":"Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery","volume":"596","author":"Pizzo","year":"2018","journal-title":"The Journal of Physiology"},{"key":"bib98","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-9","article-title":"The function and structure of the cerebrospinal fluid outflow system","volume":"7","author":"Pollay","year":"2010","journal-title":"Cerebrospinal Fluid Research"},{"key":"bib99","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1159\/000335762","article-title":"AQP5 is expressed in type-B intercalated cells in the collecting duct system of the rat, mouse and human kidney","volume":"28","author":"Procino","year":"2011","journal-title":"Cellular Physiology and Biochemistry"},{"key":"bib100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0070-2153(05)71001-2","article-title":"The choroid plexus-cerebrospinal fluid system: from development to aging","volume":"71","author":"Redzic","year":"2005","journal-title":"Current Topics in Developmental Biology"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1001\/jamaneurol.2015.2952","article-title":"Association between olfactory dysfunction and amnestic mild cognitive impairment and alzheimer disease dementia","volume":"73","author":"Roberts","year":"2016","journal-title":"JAMA Neurology"},{"key":"bib102","doi-asserted-by":"publisher","first-page":"10067","DOI":"10.1523\/JNEUROSCI.1776-10.2010","article-title":"Chromosomal location-dependent nonstochastic onset of odor receptor expression","volume":"30","author":"Rodriguez-Gil","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib103","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1139\/cjpp-2014-0157","article-title":"Distribution of aquaporin genes and selection of individual reference genes for quantitative real-time RT-PCR analysis in multiple tissues of the mouse","volume":"92","author":"Sakai","year":"2014","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"bib104","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neulet.2013.10.058","article-title":"Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease","volume":"558","author":"Semba","year":"2014","journal-title":"Neuroscience Letters"},{"key":"bib105","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1002\/cne.22459","article-title":"Olfactory ensheathing glia express aquaporin 1","volume":"518","author":"Shields","year":"2010","journal-title":"The Journal of Comparative Neurology"},{"key":"bib106","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3791\/3742","article-title":"A polished and reinforced Thinned-skull window for Long-term imaging of the mouse brain","volume":"61","author":"Shih","year":"2012","journal-title":"Journal of Visualized Experiments"},{"key":"bib107","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1152\/jn.00046.2015","article-title":"Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature","volume":"114","author":"Shirey","year":"2015","journal-title":"Journal of Neurophysiology"},{"key":"bib108","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1365-2990.2002.00373.x","article-title":"Cerebrospinal fluid outflow resistance in sheep: impact of blocking cerebrospinal fluid transport through the cribriform plate","volume":"28","author":"Silver","year":"2002","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib109","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-3-7","article-title":"Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease","volume":"3","author":"Silverberg","year":"2006","journal-title":"Cerebrospinal Fluid Research"},{"key":"bib110","first-page":"99","article-title":"TRIzol: a new reagent for optimal single-step isolation of RNA","volume":"15","author":"Simms","year":"1993","journal-title":"Focus"},{"key":"bib111","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.bbadis.2015.10.014","article-title":"Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease","volume":"1862","author":"Simon","year":"2016","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"bib112","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27679","article-title":"Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma","volume":"6","author":"Smith","year":"2017","journal-title":"eLife"},{"key":"bib113","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends in Neurosciences"},{"key":"bib114","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S1808-8694(15)30839-9","article-title":"Anterior ethmoidal artery evaluation on coronal CT scans","volume":"75","author":"Souza","year":"2009","journal-title":"Brazilian Journal of Otorhinolaryngology"},{"key":"bib115","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-3806(83)90009-3","article-title":"The effect of intranasal zinc sulfate treatment on odor-mediated behavior and on odor-induced metabolic activity in the olfactory bulbs of neonatal rats","volume":"8","author":"Stewart","year":"1983","journal-title":"Developmental Brain Research"},{"key":"bib116","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1152\/physrev.00027.2007","article-title":"Diffusion in brain extracellular space","volume":"88","author":"Sykov\u00e1","year":"2008","journal-title":"Physiological Reviews"},{"key":"bib117","doi-asserted-by":"publisher","first-page":"F835","DOI":"10.1152\/ajprenal.1984.246.6.F835","article-title":"Drainage of interstitial fluid from different regions of rat brain","volume":"246","author":"Szentistvanyi","year":"1984","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"bib118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.proghi.2004.03.001","article-title":"Aquaporins: water channel proteins of the cell membrane","volume":"39","author":"Takata","year":"2004","journal-title":"Progress in Histochemistry and Cytochemistry"},{"key":"bib119","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/337736a0","article-title":"Pathological changes in olfactory neurons in patients with Alzheimer's disease","volume":"337","author":"Talamo","year":"1989","journal-title":"Nature"},{"key":"bib120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.1991.tb00182.x","article-title":"Pathologic changes in olfactory neurons in Alzheimer's disease","volume":"640","author":"Talamo","year":"1991","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib121","doi-asserted-by":"publisher","first-page":"14553","DOI":"10.1523\/JNEUROSCI.3287-09.2009","article-title":"Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels","volume":"29","author":"Tsai","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"bib122","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00276-016-1650-9","article-title":"A possible venous connection between the cranial and nasal cavity","volume":"38","author":"Tsutsumi","year":"2016","journal-title":"Surgical and Radiologic Anatomy"},{"key":"bib123","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00276-019-02208-9","article-title":"An undescribed venous pathway intervening between the olfactory fossa and nasal vestibule","volume":"41","author":"Tsutsumi","year":"2019","journal-title":"Surgical and Radiologic Anatomy"},{"key":"bib124","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/jcbfm.1990.110","article-title":"Neuropeptide Y and the cerebral circulation","volume":"10","author":"Tuor","year":"1990","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib125","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.tins.2018.07.008","article-title":"Neural sensing of organ volume","volume":"41","author":"Umans","year":"2018","journal-title":"Trends in Neurosciences"},{"key":"bib126","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1159\/000452168","article-title":"Aquaporin water channels and hydrocephalus","volume":"52","author":"Verkman","year":"2017","journal-title":"Pediatric Neurosurgery"},{"key":"bib127","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1365-2990.2006.00737.x","article-title":"The olfactory route for cerebrospinal fluid drainage into the peripheral lymphatic system","volume":"32","author":"Walter","year":"2006","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib128","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1073\/pnas.1414821112","article-title":"In vivo albumin labeling and lymphatic imaging","volume":"112","author":"Wang","year":"2015","journal-title":"PNAS"},{"key":"bib129","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/aja.1000310302","article-title":"The absorption of cerebrospinal fluid into the venous system","volume":"31","author":"Weed","year":"1923","journal-title":"American Journal of Anatomy"},{"key":"bib130","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1093\/brain\/83.3.454","article-title":"The cerebrospinal fluid valves","volume":"83","author":"Welch","year":"1960","journal-title":"Brain"},{"key":"bib131","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1750-3639.1992.tb00704.x","article-title":"Pathways of fluid drainage from the brain--morphological aspects and immunological significance in rat and man","volume":"2","author":"Weller","year":"1992","journal-title":"Brain Pathology"},{"key":"bib132","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s00401-018-1809-z","article-title":"The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS","volume":"135","author":"Weller","year":"2018","journal-title":"Acta Neuropathologica"},{"key":"bib133","doi-asserted-by":"publisher","first-page":"4498","DOI":"10.1073\/pnas.76.9.4498","article-title":"Fluorescent phallotoxin, a tool for the visualization of cellular actin","volume":"76","author":"Wulf","year":"1979","journal-title":"PNAS"},{"key":"bib134","doi-asserted-by":"publisher","first-page":"H1197","DOI":"10.1152\/ajpheart.1991.261.4.H1197","article-title":"Albumin outflow into deep cervical lymph from different regions of rabbit brain","volume":"261","author":"Yamada","year":"1991","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"bib135","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/jnr.22018","article-title":"The influence of NF-kappaB signal-transduction pathways on the murine inner ear by acoustic overstimulation","volume":"87","author":"Yamamoto","year":"2009","journal-title":"Journal of Neuroscience Research"},{"key":"bib136","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1055\/s-0028-1115323","article-title":"Morphological characteristics of the anterior ethmoidal artery in Ethmoid roof and endoscopic localization","volume":"19","author":"Yang","year":"2009","journal-title":"Skull Base"},{"key":"bib137","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-107","article-title":"Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer","volume":"11","author":"Yang","year":"2013","journal-title":"Journal of Translational Medicine"},{"key":"bib138","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.mvr.2003.08.004","article-title":"Integrating the roles of extracranial lymphatics and intracranial veins in cerebrospinal fluid absorption in sheep","volume":"67","author":"Zakharov","year":"2004","journal-title":"Microvascular Research"},{"key":"bib139","doi-asserted-by":"publisher","first-page":"869","DOI":"10.2147\/NDT.S104886","article-title":"Olfactory dysfunction in Alzheimer's disease","volume":"12","author":"Zou","year":"2016","journal-title":"Neuropsychiatric Disease and Treatment"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44278\/elife-44278-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44278\/elife-44278-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/44278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:55:06Z","timestamp":1697057706000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/44278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":139,"alternative-id":["10.7554\/eLife.44278"],"URL":"https:\/\/doi.org\/10.7554\/elife.44278","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/485995","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.44278.024","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.44278.025","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"article-number":"e44278"}}