{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:51:12Z","timestamp":1790927472639,"version":"4.1.0"},"reference-count":69,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0516"],"award-info":[{"award-number":["W81XWH-16-1-0516"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","award":["Henry L Brasza endowment"],"award-info":[{"award-number":["Henry L Brasza endowment"]}],"id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL113508"],"award-info":[{"award-number":["R01HL113508"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007284","name":"School of Medicine, Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1\/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14\n                    <jats:sup>+<\/jats:sup>\n                    monocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoidosis. Further investigation revealed that sarcoidosis macrophages and monocytes exhibit higher protein levels for HIF-\u03b1 isoforms, HIF-1\u03b2, and their transcriptional co-activator p300 as well as glucose transporter 1 (Glut1). In situ hybridization of sarcoidosis granulomatous lung tissues showed abundance of HIF-1\u03b1 in the center of granulomas. The abundance of HIF isoforms was mechanistically linked to elevated IL-1\u03b2 and IL-17 since targeted down regulation of HIF-1\u03b1 via short interfering RNA or a HIF-1\u03b1 inhibitor decreased their production. Pharmacological intervention using chloroquine, a lysosomal inhibitor, decreased lysosomal associated protein 2 (LAMP2) and HIF-1\u03b1 levels and modified cytokine production. These data suggest that increased activity of HIF-\u03b1 isoforms regulate Th1\/Th17 mediated inflammation in sarcoidosis.\n                  <\/jats:p>","DOI":"10.7554\/elife.44519","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T08:01:56Z","timestamp":1554364916000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.44519","source":"Crossref","is-referenced-by-count":59,"title":["HIF-1\u03b1 regulates IL-1\u03b2 and IL-17 in sarcoidosis"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-6500","authenticated-orcid":true,"given":"Jaya","family":"Talreja","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvinder","family":"Talwar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bauerfeld","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence I","family":"Grossman","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tranchida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3327-2585","authenticated-orcid":true,"given":"Lobelia","family":"Samavati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/cei.12170","article-title":"Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing","volume":"174","author":"Aberdein","year":"2013","journal-title":"Clinical and Experimental Immunology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1136\/ard.59.suppl_1.i60","article-title":"Biological role of interleukin 1 receptor antagonist isoforms","volume":"59","author":"Arend","year":"2000","journal-title":"Annals of the Rheumatic Diseases"},{"key":"bib3","first-page":"930","article-title":"GLUT1 expression in tissue and (18)F-FDG uptake","volume":"45","author":"Avril","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2967\/jnumed.108.054205","article-title":"18F-FDG PET and PET\/CT in the evaluation of cancer treatment response","volume":"50","author":"Ben-Haim","year":"2009","journal-title":"Journal of Nuclear Medicine"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"9519","DOI":"10.1074\/jbc.M010144200","article-title":"Regulation of glut1 mRNA by hypoxia-inducible factor-1. interaction between H-ras and hypoxia","volume":"276","author":"Chen","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17 cell differentiation by interleukin-1 signaling","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1365-2036.1996.22164020.x","article-title":"Interleukin-1 and interleukin-1 receptor antagonist in inflammatory bowel disease","volume":"10","author":"Cominelli","year":"1996","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mam.2015.12.004","article-title":"The role of HIF in immunity and inflammation","volume":"47-48","author":"Cummins","year":"2016","journal-title":"Molecular Aspects of Medicine"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.4049\/jimmunol.1302734","article-title":"IL-1\u03b2 promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1\/17 cells that are specific for pathogenic and commensal microbes","volume":"193","author":"Duhen","year":"2014","journal-title":"The Journal of Immunology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/thx.2010.140319","article-title":"Sarcoidosis is a Th1\/Th17 multisystem disorder","volume":"66","author":"Facco","year":"2011","journal-title":"Thorax"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1136\/thx.47.11.964","article-title":"B lymphocyte accumulations in human pulmonary sarcoidosis","volume":"47","author":"Fazel","year":"1992","journal-title":"Thorax"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0076-6879(07)35021-0","article-title":"Regulation of hypoxia-inducible factors during inflammation","volume":"435","author":"Frede","year":"2007","journal-title":"Methods in enzymology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-015-0932-2","article-title":"Metabolomics connects aberrant bioenergetic, Transmethylation, and gut microbiota in sarcoidosis","volume":"12","author":"Geamanu","year":"2016","journal-title":"Metabolomics"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1189\/jlb.0602313","article-title":"Interleukin-18","volume":"73","author":"Gracie","year":"2003","journal-title":"Journal of Leukocyte Biology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"ra44","DOI":"10.1126\/scisignal.2001450","article-title":"Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response","volume":"4","author":"He","year":"2011","journal-title":"Science Signaling"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1128\/mcb.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"ra24","DOI":"10.1126\/scisignal.aaa2147","article-title":"Control of IL-17 receptor signaling and tissue inflammation by the p38\u03b1-MKP-1 signaling axis in a mouse model of multiple sclerosis","volume":"8","author":"Huang","year":"2015","journal-title":"Science Signaling"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1164\/ajrccm.149.4.8143052","article-title":"Outcome of the treatment for sarcoidosis","volume":"149","author":"Hunninghake","year":"1994","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"bib21","first-page":"149","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. american thoracic society\/European respiratory society\/World association of sarcoidosis and other granulomatous disorders","volume":"16","author":"Hunninghake","year":"1999","journal-title":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"New England Journal of Medicine"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.4049\/jimmunol.147.12.4218","article-title":"Production of IL-1 receptor antagonist by human in vitro-derived macrophages. effects of lipopolysaccharide and granulocyte-macrophage colony-stimulating factor","volume":"147","author":"Janson","year":"1991","journal-title":"Journal of Immunology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg's contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nature Reviews Cancer"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.4049\/jimmunol.161.12.6871","article-title":"The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness","volume":"161","author":"Lang","year":"1998","journal-title":"Journal of Immunology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.4049\/jimmunol.1302470","article-title":"Blockade of IL-6 trans signaling attenuates pulmonary fibrosis","volume":"193","author":"Le","year":"2014","journal-title":"Journal of Immunology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/emm.2004.1","article-title":"Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions","volume":"36","author":"Lee","year":"2004","journal-title":"Experimental & Molecular Medicine"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1182\/blood-2009-08-236521","article-title":"Regulating human Th17 cells via differential expression of IL-1 receptor","volume":"115","author":"Lee","year":"2010","journal-title":"Blood"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrneph.2011.150","article-title":"The role of antimalarial agents in the treatment of SLE and lupus nephritis","volume":"7","author":"Lee","year":"2011","journal-title":"Nature Reviews Nephrology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"17733","DOI":"10.3390\/ijms151017733","article-title":"TCDD induces the hypoxia-inducible factor (HIF)-1\u03b1 regulatory pathway in human trophoblastic JAR cells","volume":"15","author":"Liao","year":"2014","journal-title":"International Journal of Molecular Sciences"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia\/reperfusion injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1159\/000029536","article-title":"Significance of the interleukin-1 receptor antagonist\/interleukin-1 beta ratio as a prognostic factor in patients with pulmonary sarcoidosis","volume":"67","author":"Mikuniya","year":"2000","journal-title":"Respiration"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1084\/jem.20050648","article-title":"The immune paradox of sarcoidosis and regulatory T cells","volume":"203","author":"Miyara","year":"2006","journal-title":"The Journal of Experimental Medicine"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/0002-9343(61)90213-3","article-title":"The treatment of sarcoidosis with chloroquine","volume":"30","author":"Morse","year":"1961","journal-title":"The American Journal of Medicine"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1183\/09031936.98.12030716","article-title":"Sarcoidosis: immunopathogenetic concepts and their clinical application","volume":"12","author":"M\u00fcller-Quernheim","year":"1998","journal-title":"European Respiratory Journal"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nri2607","article-title":"Interdependence of hypoxic and innate immune responses","volume":"9","author":"Nizet","year":"2009","journal-title":"Nature Reviews Immunology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1182\/blood-2011-02-336552","article-title":"Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis","volume":"118","author":"Noubade","year":"2011","journal-title":"Blood"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cei.12403","article-title":"Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with l\u00f6fgren's syndrome","volume":"178","author":"Ostadkarampour","year":"2014","journal-title":"Clinical & Experimental Immunology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","article-title":"HIF transcription factors, inflammation, and immunity","volume":"41","author":"Palazon","year":"2014","journal-title":"Immunity"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.4049\/jimmunol.178.12.7516","article-title":"Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis","volume":"178","author":"Peyssonnaux","year":"2007","journal-title":"The Journal of Immunology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.molimm.2015.08.004","article-title":"Hypoxia-inducible factors regulate T cell metabolism and function","volume":"68","author":"Phan","year":"2015","journal-title":"Molecular Immunology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1164\/rccm.201507-1499OC","article-title":"IFN-\u03b3-Producing T-Helper 17.1 cells are increased in Sarcoidosis and are more prevalent than T-Helper type 1 cells","volume":"193","author":"Ramstein","year":"2016","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1164\/rccm.201005-0792OC","article-title":"Dysregulation of p38 and MKP-1 in response to NOD1\/TLR4 stimulation in sarcoid bronchoalveolar cells","volume":"183","author":"Rastogi","year":"2011","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1164\/ajrccm\/148.5.1378","article-title":"Interleukin-1 receptor antagonist expression in sarcoidosis","volume":"148","author":"Rolfe","year":"1993","journal-title":"American Review of Respiratory Disease"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nrd2272","article-title":"Potential therapeutic applications of autophagy","volume":"6","author":"Rubinsztein","year":"2007","journal-title":"Nature Reviews Drug Discovery"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"22642","DOI":"10.1074\/jbc.272.36.22642","article-title":"Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. its stabilization by hypoxia depends on redox-induced changes","volume":"272","author":"Salceda","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.molimm.2009.02.018","article-title":"STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria","volume":"46","author":"Samavati","year":"2009","journal-title":"Molecular Immunology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fimmu.2013.00182","article-title":"IL-1 and T helper immune responses","volume":"4","author":"Santarlasci","year":"2013","journal-title":"Frontiers in Immunology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nature Reviews Cancer"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1053\/j.semnuclmed.2013.06.007","article-title":"FDG PET imaging in sarcoidosis","volume":"43","author":"Sobic-Saranovic","year":"2013","journal-title":"Seminars in Nuclear Medicine"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.4049\/jimmunol.1600258","article-title":"Dual inhibition of Rip2 and IRAK1\/4 regulates IL-1\u03b2 and IL-6 in sarcoidosis alveolar macrophages and peripheral blood mononuclear cells","volume":"197","author":"Talreja","year":"2016","journal-title":"The Journal of Immunology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1038\/s41598-017-02941-4","article-title":"RNA-sequencing identifies novel pathways in sarcoidosis monocytes","volume":"7","author":"Talreja","year":"2017","journal-title":"Scientific Reports"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2017.02.018","article-title":"MKP-1 negatively regulates LPS-mediated IL-1\u03b2 production through p38 activation and HIF-1\u03b1 expression","volume":"34","author":"Talwar","year":"2017","journal-title":"Cellular Signalling"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.dib.2017.07.036","article-title":"The dataset describes: hif-1 \u03b1 expression and LPS mediated cytokine production in MKP-1 deficient bone marrow derived murine macrophages","volume":"14","author":"Talwar","year":"2017","journal-title":"Data in Brief"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.4049\/jimmunol.1801477","article-title":"MEK2 negatively regulates Lipopolysaccharide-Mediated IL-1\u03b2 production through HIF-1\u03b1 expression","volume":"202","author":"Talwar","year":"2019","journal-title":"The Journal of Immunology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/jgh.12038","article-title":"Hypoxia-inducible factor-1 as a therapeutic target in cancer","volume":"28","author":"Tang","year":"2013","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1182\/blood-2013-05-500207","article-title":"Hypoxia-inducible factor 2\u03b1 regulates key neutrophil functions in humans, mice, and zebrafish","volume":"123","author":"Thompson","year":"2014","journal-title":"Blood"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/PL00007637","article-title":"Serum lysozyme levels and clinical features of sarcoidosis","volume":"177","author":"Tomita","year":"1999","journal-title":"Lung"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1186\/1756-0500-5-654","article-title":"Expression of hypoxia-inducible factor (HIF)-1a-vascular endothelial growth factor (VEGF)-inhibitory growth factor (ING)-4- axis in sarcoidosis patients","volume":"5","author":"Tzouvelekis","year":"2012","journal-title":"BMC Research Notes"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.1111\/j.1742-4658.2007.06072.x","article-title":"Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions","volume":"274","author":"Vlaminck","year":"2007","journal-title":"FEBS Journal"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.4161\/auto.25573","article-title":"A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy","volume":"9","author":"Wang","year":"2013","journal-title":"Autophagy"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/ni.2386","article-title":"Metabolic checkpoints in activated T cells","volume":"13","author":"Wang","year":"2012","journal-title":"Nature Immunology"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4161\/epi.5.4.11684","article-title":"Epigenetics, the epicenter of the hypoxic response","volume":"5","author":"Watson","year":"2010","journal-title":"Epigenetics"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1159\/000354487","article-title":"The aryl hydrocarbon receptor nuclear translocator (ARNT\/HIF-1\u03b2) is influenced by hypoxia and hypoxia-mimetics","volume":"32","author":"Wolff","year":"2013","journal-title":"Cellular Physiology and Biochemistry"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.cell.2018.09.042","article-title":"Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity","volume":"175","author":"Yao","year":"2018","journal-title":"Cell"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44519\/elife-44519-v3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/44519\/elife-44519-v3.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/44519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:55:34Z","timestamp":1697057734000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/44519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":69,"alternative-id":["10.7554\/eLife.44519"],"URL":"https:\/\/doi.org\/10.7554\/elife.44519","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.44519.025","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.44519.026","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]},"article-number":"e44519"}}