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However, it is unclear how these difficulties are linked to atypical early functional brain organization in ASD. With resting state fMRI data in a large sample of ASD toddlers and other non-ASD comparison groups, we find ASD-related functional hypoconnnectivity between \u2018social brain\u2019 circuitry such as the default mode network (DMN) and visual and attention networks. An eye tracking-identified ASD subtype with pronounced early social visual engagement difficulties (GeoPref ASD) is characterized by marked DMN-occipito-temporal cortex (OTC) hypoconnectivity. Increased DMN-OTC hypoconnectivity is also related to increased severity of social-communication difficulties, but only in GeoPref ASD. Early and pronounced social-visual circuit hypoconnectivity is a key underlying neurobiological feature describing GeoPref ASD and may be critical for future social-communicative development and represent new treatment targets for early intervention in these individuals.<\/jats:p>","DOI":"10.7554\/elife.47427","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T19:00:23Z","timestamp":1576522823000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.47427","source":"Crossref","is-referenced-by-count":77,"title":["Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-8619","authenticated-orcid":true,"given":"Michael V","family":"Lombardo","sequence":"first","affiliation":[{"name":"Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto 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