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However, there is still no direct evidence on CeA GABAergic neurons\u2019 real-time dynamic during cataplexy. We used a deep brain calcium imaging tool to image the intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mice by expressing the calcium sensor GCaMP6 into genetically defined CeA GABAergic neurons. Two distinct GABAergic neuronal groups involved in cataplexy were identified: spontaneous cataplexy-ON and predator odor-induced cataplexy-ON neurons. Majority in the latter group were inactive during regular sleep\/wake cycles but were specifically activated by predator odor and continued their intense activities into succeeding cataplexy bouts. Furthermore, we found that CeA GABAergic neurons became highly synchronized during predator odor-induced cataplexy. We suggest that the abnormal activation and synchronization of CeA GABAergic neurons may trigger emotion-induced cataplexy.<\/jats:p>","DOI":"10.7554\/elife.48311","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T08:00:42Z","timestamp":1565769642000},"source":"Crossref","is-referenced-by-count":18,"title":["Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy"],"prefix":"10.7554","volume":"8","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Blanco-Centurion","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, United 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