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We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats.<\/jats:p>","DOI":"10.7554\/elife.48401","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T08:00:24Z","timestamp":1580716824000},"source":"Crossref","is-referenced-by-count":120,"title":["Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-073X","authenticated-orcid":true,"given":"Cara E","family":"Brook","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, University of California, Berkeley, Berkeley, United States"},{"name":"Department of Ecology and Evolutionary Biology, Princeton University, Princeton, United 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