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We investigated the underlying mechanisms using the developing tracheal tube network of Drosophila indirect flight muscles (IFMs) as a model. Live imaging revealed that tracheal sprouts invade IFMs directionally with growth-cone-like structures at branch tips. Ramification inside IFMs proceeds until tracheal branches fill the myotube. However, individual tracheal cells occupy largely separate territories, possibly mediated by cell-cell repulsion. Matrix metalloproteinase 1 (MMP1) is required in tracheal cells for normal invasion speed and for the dynamic organization of growth-cone-like branch tips. MMP1 remodels the CollagenIV-containing matrix around branch tips, which show differential matrix composition with low CollagenIV levels, while Laminin is present along tracheal branches. Thus, tracheal-derived MMP1 sustains branch invasion by modulating the dynamic behavior of sprouting branches as well as properties of the surrounding matrix.<\/jats:p>","DOI":"10.7554\/elife.48857","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T08:00:19Z","timestamp":1570003219000},"source":"Crossref","is-referenced-by-count":29,"title":["Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles"],"prefix":"10.7554","volume":"8","author":[{"given":"Julia","family":"Sauerwald","sequence":"first","affiliation":[{"name":"Institute for Zoophysiology, University of M\u00fcnster, M\u00fcnster, Germany"},{"name":"Cluster of Excellence EXC 1003, Cells in Motion (CiM), M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Backer","sequence":"additional","affiliation":[{"name":"Institute for Zoophysiology, University of M\u00fcnster, 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