{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:34:53Z","timestamp":1781940893448,"version":"3.54.5"},"reference-count":48,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2311-B-715-001"],"award-info":[{"award-number":["107-2311-B-715-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107--2314-B-303-003"],"award-info":[{"award-number":["107--2314-B-303-003"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liver Disease Prevention and Treatment Research Foundation, Taiwan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>NogoA inhibits neurite outgrowth of motoneurons (NOM) through interaction with its receptors, Nogo66\/NgR. Inhibition of Nogo receptors rescues NOM, but not to the extent exhibited by NogoA-knockout mice, suggesting the presence of other pathways. We found that NogoA-overexpressing muscle cells reduced phosphoglycerate kinase 1 (Pgk1) secretion, resulting in inhibiting NOM. Apart from its glycolytic role and independent of the Nogo66 pathway, extracellular Pgk1 stimulated NOM by triggering a reduction of p-Cofilin-S3, a growth cone collapse marker, through decreasing a novel Rac1-GTP\/p-Pak1-T423\/p-P38-T180\/p-MK2-T334\/p-Limk1-S323\/p-Cofilin-S3 molecular pathway. Not only did supplementary Pgk1 enhance NOM in defective cells, but injection of Pgk1 rescued denervation in muscle-specific NogoA-overexpression of zebrafish and an Amyotrophic Lateral Sclerosis mouse model, SOD1 G93A. Thus, Pgk1 secreted from muscle is detrimental to motoneuron neurite outgrowth and maintenance.<\/jats:p>","DOI":"10.7554\/elife.49175","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T10:10:41Z","timestamp":1564481441000},"source":"Crossref","is-referenced-by-count":26,"title":["Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66\/NgR-independent targeting of NogoA"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9570-0218","authenticated-orcid":true,"given":"Cheng Yung","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia Lun","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, 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