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However, the initial formation of taste buds is proposed to be nerve-independent in amphibians, and evidence to the contrary in mammals has been endlessly debated, mostly due to indirect and incomplete means to impede innervation during the protracted perinatal period of taste bud differentiation. Here, by genetically ablating, in mice, all somatic (i.e. touch) or visceral (i.e. taste) neurons for the oral cavity, we show that the latter but not the former are absolutely required for the proper formation of their target organs, the taste buds.<\/jats:p>","DOI":"10.7554\/elife.49226","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T20:26:13Z","timestamp":1569875173000},"source":"Crossref","is-referenced-by-count":17,"title":["Taste bud formation depends on taste nerves"],"prefix":"10.7554","volume":"8","author":[{"given":"Di","family":"Fan","sequence":"first","affiliation":[{"name":"Institut de Biologie de l\u2019ENS (IBENS), Inserm, CNRS, \u00c9cole normale sup\u00e9rieure, PSL Research University, Paris, France"},{"name":"School of Life Science, East China Normal University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoubida","family":"Chettouh","sequence":"additional","affiliation":[{"name":"Institut 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