{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:42:48Z","timestamp":1790433768176,"version":"4.1.0"},"reference-count":108,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"crossref","award":["666992"],"award-info":[{"award-number":["666992"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013371","name":"Universit\u00e9 C\u00f4te d\u2019Azur","doi-asserted-by":"crossref","award":["UCAJEDI ANX 15 IDEX 01"],"award-info":[{"award-number":["UCAJEDI ANX 15 IDEX 01"]}],"id":[{"id":"10.13039\/501100013371","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approaches for evaluating the influence of connectivity on neurodegeneration consider each descriptor in isolation and match predictions against late-stage atrophy patterns. We introduce the notion of a topological profile \u2014 a characteristic combination of topological descriptors that best describes the propagation of pathology in a particular disease. By drawing on recent advances in disease progression modeling, we estimate topological profiles from the full course of pathology accumulation, at both cohort and individual levels. Experimental results comparing topological profiles for Alzheimer\u2019s disease, multiple sclerosis and normal ageing show that topological profiles explain the observed data better than single descriptors. Within each condition, most individual profiles cluster around the cohort-level profile, and individuals whose profiles align more closely with other cohort-level profiles show features of that cohort. The cohort-level profiles suggest new insights into the biological mechanisms underlying pathology propagation in each disease.<\/jats:p>","DOI":"10.7554\/elife.49298","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T08:00:20Z","timestamp":1575360020000},"source":"Crossref","is-referenced-by-count":15,"title":["Differences in topological progression profile among neurodegenerative diseases from imaging data"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-3630","authenticated-orcid":true,"given":"Sara","family":"Garbarino","sequence":"first","affiliation":[{"name":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"},{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Inria, Epione Research Project, Sophia Antipolis, 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-3706","authenticated-orcid":true,"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"},{"name":"Department of Radiology and Nuclear medicine, VUmc, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Schott","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Institute of Neurology, University College London, London, United 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