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The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the microprocessor complex required for miRNA synthesis. Comparison of the miRNA profiles between wildtype and SUN1 null myotubes identified a cluster of miRNAs encoded by a non-translated retrotransposon-like one antisense (Rtl1as) transcript that are decreased in the WT myoblasts due to SUN1 inhibition of Drosha. One of these miRNAs miR-127 inhibits the translation of the Rtl1 sense transcript, that encodes the retrotransposon-like one protein (RTL1), which is also required for muscle regeneration and is expressed in regenerating\/dystrophic muscle. The LINC complex may therefore regulate gene expression during muscle regeneration by controlling miRNA processing. This provides new insights into the molecular pathology underlying muscular dystrophies and how the LINC complex may regulate mechanosignaling.<\/jats:p>","DOI":"10.7554\/elife.49485","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T08:01:55Z","timestamp":1572940915000},"source":"Crossref","is-referenced-by-count":13,"title":["The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-6469","authenticated-orcid":true,"given":"Tsui Han","family":"Loo","sequence":"first","affiliation":[{"name":"Developmental and Regenerative Biology, Institute of Medical Biology, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Ye","sequence":"additional","affiliation":[{"name":"Developmental and Regenerative Biology, Institute of Medical Biology, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth Jinfen","family":"Chai","sequence":"additional","affiliation":[{"name":"Developmental and Regenerative Biology, Institute of Medical Biology, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuteru","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gis\u00e8le","family":"Bonne","sequence":"additional","affiliation":[{"name":"Center of Research in Myology, Institut de Myologie, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM UMRS 974, CNRS FRE 3617, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C","family":"Ferguson-Smith","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Cambridge, Cambridge, United 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