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Mancina et al., 2016; Luukkonen et al., 2016; Thabet et al., 2016; Viitasalo et al., 2016; Krawczyk et al., 2017; Thabet et al., 2017). Based on hepatic expression quantitative trait loci analysis, it has been suggested that\n                    <jats:italic>MBOAT7<\/jats:italic>\n                    loss of function promotes liver disease progression (Buch et al., 2015; Mancina et al., 2016; Luukkonen et al., 2016; Thabet et al., 2016; Viitasalo et al., 2016; Krawczyk et al., 2017; Thabet et al., 2017), but this has never been formally tested. Here we show that\n                    <jats:italic>Mboat7<\/jats:italic>\n                    loss, but not\n                    <jats:italic>Tmc4<\/jats:italic>\n                    , in mice is sufficient to promote the progression of NAFLD in the setting of high fat diet.\n                    <jats:italic>Mboat7<\/jats:italic>\n                    loss of function is associated with accumulation of its substrate lysophosphatidylinositol (LPI) lipids, and direct administration of LPI promotes hepatic inflammatory and fibrotic transcriptional changes in an\n                    <jats:italic>Mboat7<\/jats:italic>\n                    -dependent manner. These studies reveal a novel role for MBOAT7-driven acylation of LPI lipids in suppressing the progression of NAFLD.\n                  <\/jats:p>","DOI":"10.7554\/elife.49882","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T08:00:19Z","timestamp":1571299219000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.49882","source":"Crossref","is-referenced-by-count":116,"title":["Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease"],"prefix":"10.7554","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-3187","authenticated-orcid":true,"given":"Robert N","family":"Helsley","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States"},{"name":"Department of Internal Medicine, University of Cincinnati, Cincinnati, United 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