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Here we define the logic of this transformation in a Caenorhabditis elegans integrating interneuron. AIA interneurons receive input from multiple chemosensory neurons that detect attractive odors. We show that reliable AIA responses require the coincidence of two sensory inputs: activation of AWA olfactory neurons that are activated by attractive odors, and inhibition of one or more chemosensory neurons that are inhibited by attractive odors. AWA activates AIA through an electrical synapse, while the disinhibitory pathway acts through glutamatergic chemical synapses. AIA interneurons have bistable electrophysiological properties consistent with their calcium dynamics, suggesting that AIA activation is a stereotyped response to an integrated stimulus. Our results indicate that AIA interneurons combine sensory information using AND-gate logic, requiring coordinated activity from multiple chemosensory neurons. We propose that AIA encodes positive valence based on an integrated sensory state.<\/jats:p>","DOI":"10.7554\/elife.50566","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T08:00:15Z","timestamp":1573632015000},"source":"Crossref","is-referenced-by-count":47,"title":["Reliability of an interneuron response depends on an integrated sensory state"],"prefix":"10.7554","volume":"8","author":[{"given":"May","family":"Dobosiewicz","sequence":"first","affiliation":[{"name":"Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-0618","authenticated-orcid":true,"given":"Cornelia I","family":"Bargmann","sequence":"additional","affiliation":[{"name":"Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States"},{"name":"Chan Zuckerberg Initiative, Palo Alto, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1460-9568.2007.05686.x","article-title":"The chemical component of the mixed GF-TTMn synapse in Drosophila Melanogaster uses acetylcholine as its neurotransmitter","volume":"26","author":"Allen","year":"2007","journal-title":"European Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"key":"bib3","article-title":"Chemosensation in C. elegans WormBook, ed. 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