{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:59:13Z","timestamp":1793138353514,"version":"4.5.0"},"reference-count":43,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGY0069"],"award-info":[{"award-number":["RGY0069"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["FLEXNEURO 716643"],"award-info":[{"award-number":["FLEXNEURO 716643"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS089521"],"award-info":[{"award-number":["NS089521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH107620"],"award-info":[{"award-number":["MH107620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS108410"],"award-info":[{"award-number":["NS108410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Over days and weeks, neural activity representing an animal\u2019s position and movement in sensorimotor cortex has been found to continually reconfigure or \u2018drift\u2019 during repeated trials of learned tasks, with no obvious change in behavior. This challenges classical theories, which assume stable engrams underlie stable behavior. However, it is not known whether this drift occurs systematically, allowing downstream circuits to extract consistent information. Analyzing long-term calcium imaging recordings from posterior parietal cortex in mice (\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    ), we show that drift is systematically constrained far above chance, facilitating a linear weighted readout of behavioral variables. However, a significant component of drift continually degrades a fixed readout, implying that drift is not confined to a null coding space. We calculate the amount of plasticity required to compensate drift independently of any learning rule, and find that this is within physiologically achievable bounds. We demonstrate that a simple, biologically plausible local learning rule can achieve these bounds, accurately decoding behavior over many days.\n                  <\/jats:p>","DOI":"10.7554\/elife.51121","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T20:00:52Z","timestamp":1594670452000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.51121","source":"Crossref","is-referenced-by-count":113,"title":["Stable task information from an unstable neural population"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-774X","authenticated-orcid":true,"given":"Michael E","family":"Rule","sequence":"first","affiliation":[{"name":"Department of Engineering, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna R","family":"Loback","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruva V","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura N","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Stanford University, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-0158","authenticated-orcid":true,"given":"Timothy","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"E5078","DOI":"10.1073\/pnas.1320116110","article-title":"A theory for how sensorimotor skills are learned and retained in noisy and nonstationary neural circuits","volume":"110","author":"Ajemian","year":"2013","journal-title":"PNAS"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev.neuro.20.1.303","article-title":"Multimodal representation of space in the posterior parietal cortex and its use in planning movements","volume":"20","author":"Andersen","year":"1997","journal-title":"Annual Review of Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.neuro.25.112701.142922","article-title":"Intentional maps in posterior parietal cortex","volume":"25","author":"Andersen","year":"2002","journal-title":"Annual Review of Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nature14467","article-title":"Impermanence of dendritic spines in live adult CA1 Hippocampus","volume":"523","author":"Attardo","year":"2015","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.nlm.2008.09.015","article-title":"Where am I and how will I get there from here? 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