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A ubiquitous motif for maintaining this balance is the somatostatin interneuron (SOM-IN) feedback microcircuit. Here, we investigated the modulation of this microcircuit by presynaptic GABAB receptors (GABABRs) in the rodent hippocampus. Whole-cell recordings from SOM-INs revealed that both excitatory and inhibitory synaptic inputs are strongly inhibited by GABABRs, while optogenetic activation of the interneurons shows that their inhibitory output is also strongly suppressed. Electron microscopic analysis of immunogold-labelled freeze-fracture replicas confirms that GABABRs are highly expressed presynaptically at both input and output synapses of SOM-INs. Activation of GABABRs selectively suppresses the recruitment of SOM-INs during gamma oscillations induced in vitro. Thus, axonal GABABRs are positioned to efficiently control the input and output synapses of SOM-INs and can functionally uncouple them from local network with implications for rhythmogenesis and the balance of entorhinal versus intrahippocampal afferents.<\/jats:p>","DOI":"10.7554\/elife.51156","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T08:00:41Z","timestamp":1582099241000},"source":"Crossref","is-referenced-by-count":45,"title":["Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-9873","authenticated-orcid":true,"given":"Sam A","family":"Booker","sequence":"first","affiliation":[{"name":"Institute for Integrative Neuroanatomy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United 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