{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:05:22Z","timestamp":1790744722974,"version":"4.1.0"},"reference-count":94,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["Intramural research program"],"award-info":[{"award-number":["Intramural research program"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS081297"],"award-info":[{"award-number":["NS081297"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS074972"],"award-info":[{"award-number":["NS074972"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH071679"],"award-info":[{"award-number":["MH071679"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-MH111529"],"award-info":[{"award-number":["R01-MH111529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3MH120096"],"award-info":[{"award-number":["UG3MH120096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Friends of FACES Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>In violation of Dale\u2019s principle several neuronal subtypes utilize more than one classical neurotransmitter. Molecular identification of vesicular glutamate transporter three and cholecystokinin expressing cortical interneurons (CCK+VGluT3+INTs) has prompted speculation of GABA\/glutamate corelease from these cells for almost two decades despite a lack of direct evidence. We unequivocally demonstrate CCK+VGluT3+INT-mediated GABA\/glutamate cotransmission onto principal cells in adult mice using paired recording and optogenetic approaches. Although under normal conditions, GABAergic inhibition dominates CCK+VGluT3+INT signaling, glutamatergic signaling becomes predominant when glutamate decarboxylase (GAD) function is compromised. CCK+VGluT3+INTs exhibit surprising anatomical diversity comprising subsets of all known dendrite targeting CCK+ interneurons in addition to the expected basket cells, and their extensive circuit innervation profoundly dampens circuit excitability under normal conditions. However, in contexts where the glutamatergic phenotype of CCK+VGluT3+INTs is amplified, they promote paradoxical network hyperexcitability which may be relevant to disorders involving GAD dysfunction such as schizophrenia or vitamin B6 deficiency.<\/jats:p>","DOI":"10.7554\/elife.51996","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T08:00:20Z","timestamp":1581580820000},"source":"Crossref","is-referenced-by-count":52,"title":["Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-1336","authenticated-orcid":true,"given":"Kenneth A","family":"Pelkey","sequence":"first","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Calvigioni","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Fang","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Vargish","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Ekins","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Auville","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C","family":"Wester","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Lai","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Mackenzie-Gray Scott","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yuan","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hunt","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Abebe","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, NYU, Abu-Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordane","family":"Dimidschstein","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Fishell","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States"},{"name":"Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Chittajallu","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-0157","authenticated-orcid":true,"given":"Chris J","family":"McBain","sequence":"additional","affiliation":[{"name":"<italic>Eunice Kennedy Shriver<\/italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1523\/JNEUROSCI.5196-09.2010","article-title":"VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety","volume":"30","author":"Amilhon","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"9151","DOI":"10.1523\/JNEUROSCI.21-23-09151.2001","article-title":"Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons","volume":"21","author":"Andrasfalvy","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1113\/jphysiol.2011.223669","article-title":"Basket cell dichotomy in microcircuit function","volume":"590","author":"Armstrong","year":"2012","journal-title":"The Journal of Physiology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1113\/jphysiol.1995.sp020974","article-title":"Pre- and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices","volume":"488\u00a0Pt 2","author":"Barnes-Davies","year":"1995","journal-title":"The Journal of Physiology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0006-8993(72)90281-8","article-title":"The influence of semicarbazide-induced depletion of -aminobutyric acid on presynaptic inhibition","volume":"43","author":"Bell","year":"1972","journal-title":"Brain Research"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1542\/peds.20.1.33","article-title":"Intake of vitamin B6 and infantile convulsions: a first approximation of requirements of pyridoxine in infants","volume":"20","author":"Bessey","year":"1957","journal-title":"Pediatrics"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/hipo.22141","article-title":"Quantitative assessment of CA1 local circuits: knowledge base for interneuron-pyramidal cell connectivity","volume":"23","author":"Bezaire","year":"2013","journal-title":"Hippocampus"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.neuron.2013.12.027","article-title":"Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling","volume":"81","author":"Chuhma","year":"2014","journal-title":"Neuron"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"11112","DOI":"10.1523\/JNEUROSCI.5760-08.2009","article-title":"Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent","volume":"29","author":"Daw","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"11202","DOI":"10.1523\/JNEUROSCI.6334-09.2010","article-title":"Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in synchronous release from hippocampal cholecystokinin interneurons","volume":"30","author":"Daw","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"7121","DOI":"10.1523\/JNEUROSCI.5221-04.2005","article-title":"Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits","volume":"25","author":"De Gois","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00118","article-title":"GABAergic mechanisms in schizophrenia: linking postmortem and In Vivo Studies","volume":"8","author":"de Jonge","year":"2017","journal-title":"Frontiers in Psychiatry"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/nn.4544","article-title":"Abnormal wiring of CCK+ basket cells disrupts spatial information coding","volume":"20","author":"Del Pino","year":"2017","journal-title":"Nature Neuroscience"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/nn.4430","article-title":"A viral strategy for targeting and manipulating interneurons across vertebrate species","volume":"19","author":"Dimidschstein","year":"2016","journal-title":"Nature Neuroscience"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0079-6123(08)60227-7","article-title":"Chemical transmission and dale's principle","volume":"68","author":"Eccles","year":"1986","journal-title":"Progress in Brain Research"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrn2969","article-title":"From glutamate co-release to vesicular synergy: vesicular glutamate transporters","volume":"12","author":"El Mestikawy","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00140","article-title":"Regulation of the hippocampal network by VGLUT3-Positive CCK- GABAergic basket cells","volume":"11","author":"Fasano","year":"2017","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/28179","article-title":"Cholinergic induction of network oscillations at 40 hz in the Hippocampus in vitro","volume":"394","author":"Fisahn","year":"1998","journal-title":"Nature"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1096\/fj.201800713RR","article-title":"Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulation by striatal target cells","volume":"33","author":"Fortin","year":"2019","journal-title":"The FASEB Journal"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11396","article-title":"An essential role of acetylcholine-glutamate synergy at Habenular synapses in nicotine dependence","volume":"4","author":"Frahm","year":"2015","journal-title":"eLife"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"14488","DOI":"10.1073\/pnas.222546799","article-title":"The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate","volume":"99","author":"Fremeau","year":"2002","journal-title":"PNAS"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nbt.3443","article-title":"Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes","volume":"34","author":"Fuzik","year":"2016","journal-title":"Nature Biotechnology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nn1397","article-title":"Inhibitory synapses in the developing auditory system are glutamatergic","volume":"8","author":"Gillespie","year":"2005","journal-title":"Nature Neuroscience"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nn1688","article-title":"Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells","volume":"9","author":"Glickfeld","year":"2006","journal-title":"Nature Neuroscience"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.conb.2017.04.007","article-title":"Multi-transmitter neurons in the mammalian central nervous system","volume":"45","author":"Granger","year":"2017","journal-title":"Current Opinion in Neurobiology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"5442","DOI":"10.1523\/JNEUROSCI.22-13-05442.2002","article-title":"A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons","volume":"22","author":"Gras","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.neuropharm.2005.07.023","article-title":"Developmentally regulated expression of VGLUT3 during early post-natal life","volume":"49","author":"Gras","year":"2005","journal-title":"Neuropharmacology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nn2052","article-title":"The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone","volume":"11","author":"Gras","year":"2008","journal-title":"Nature Neuroscience"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1017\/S0012162201000767","article-title":"Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine","volume":"43","author":"Grillo","year":"2001","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1017\/S0952523811000290","article-title":"Genetic targeting and physiological features of VGLUT3+ amacrine cells","volume":"28","author":"Grimes","year":"2011","journal-title":"Visual Neuroscience"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1046\/j.1440-1754.2001.00701.x","article-title":"Pyridoxine-dependent seizures: a case report and a critical review of the literature","volume":"37","author":"Gupta","year":"2001","journal-title":"Journal of Paediatrics and Child Health"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134296","article-title":"Activity-Dependent bidirectional regulation of GAD expression in a homeostatic fashion is mediated by BDNF-Dependent and independent pathways","volume":"10","author":"Hanno-Iijima","year":"2015","journal-title":"PLOS ONE"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006387","article-title":"Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics","volume":"16","author":"Harris","year":"2018","journal-title":"PLOS Biology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/nn1542","article-title":"Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse","volume":"8","author":"Hefft","year":"2005","journal-title":"Nature Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019155","article-title":"Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum","volume":"6","author":"Higley","year":"2011","journal-title":"PLOS ONE"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.neuron.2010.02.012","article-title":"Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo","volume":"65","author":"Hnasko","year":"2010","journal-title":"Neuron"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev-physiol-020911-153315","article-title":"Neurotransmitter corelease: mechanism and physiological role","volume":"74","author":"Hnasko","year":"2012","journal-title":"Annual Review of Physiology"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1101\/384826","article-title":"Conserved cell types with divergent features between human and mouse cortex","volume-title":"bioRxiv","author":"Hodge","year":"2018"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180165","article-title":"Insights into GABAAergic system alteration in Huntington's disease","volume":"8","author":"Hsu","year":"2018","journal-title":"Open Biology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1073\/pnas.0730698100","article-title":"Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles","volume":"100","author":"Jin","year":"2003","journal-title":"PNAS"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.281.5375.419","article-title":"Corelease of two fast neurotransmitters at a central synapse","volume":"281","author":"Jonas","year":"1998","journal-title":"Science"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1113\/jphysiol.1992.sp019294","article-title":"Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices","volume":"455","author":"Jonas","year":"1992","journal-title":"The Journal of Physiology"},{"key":"bib43","first-page":"255","article-title":"Convulsant hydrazides. I. in vitro and in vivo inhibition of vitamin B6 enzymes by convulsant hydrazides","volume":"119","author":"Killam","year":"1957","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1126\/science.1149381","article-title":"Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations","volume":"321","author":"Klausberger","year":"2008","journal-title":"Science"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1113\/JP272231","article-title":"Properties and dynamics of inhibitory synaptic communication within the CA3 microcircuits of pyramidal cells and interneurons expressing parvalbumin or cholecystokinin","volume":"594","author":"Kohus","year":"2016","journal-title":"The Journal of Physiology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"18073","DOI":"10.1523\/JNEUROSCI.3573-11.2011","article-title":"Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area","volume":"31","author":"Laszt\u00f3czi","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"7993","DOI":"10.1523\/JNEUROSCI.6238-09.2010","article-title":"Distinct endocannabinoid control of GABA release at Perisomatic and dendritic synapses in the Hippocampus","volume":"30","author":"Lee","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ymthe.2016.10.010","article-title":"Correcting miR92a-vGAT-Mediated GABAergic dysfunctions rescues human Tau-Induced anxiety in mice","volume":"25","author":"Li","year":"2017","journal-title":"Molecular Therapy"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.neuron.2009.02.027","article-title":"Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach","volume":"62","author":"Lu","year":"2009","journal-title":"Neuron"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.181","article-title":"Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress","volume":"6","author":"Ma","year":"2016","journal-title":"Translational Psychiatry"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00579","article-title":"Clinical management of epilepsy with glutamic acid decarboxylase antibody positivity: the interplay between immunotherapy and Anti-epileptic drugs","volume":"9","author":"M\u00e4kel\u00e4","year":"2018","journal-title":"Frontiers in Neurology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0306-4522(00)00496-6","article-title":"Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells","volume":"102","author":"Meg\u00edas","year":"2001","journal-title":"Neuroscience"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1523\/JNEUROSCI.21-02-00444.2001","article-title":"Combining deconvolution and noise analysis for the estimation of transmitter release rates at the Calyx of held","volume":"21","author":"Neher","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"8772","DOI":"10.1523\/JNEUROSCI.0901-14.2014","article-title":"Striatal cholinergic neurotransmission requires VGLUT3","volume":"34","author":"Nelson","year":"2014","journal-title":"Journal of Neuroscience"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nn.2478","article-title":"Glutamate co-release at GABA\/glycinergic synapses is crucial for the refinement of an inhibitory map","volume":"13","author":"Noh","year":"2010","journal-title":"Nature Neuroscience"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1101\/683755","article-title":"Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits","volume-title":"bioRxiv","author":"Ol\u00e1h","year":"2019"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1523\/JNEUROSCI.4681-14.2015","article-title":"VGluT3-expressing CCK-positive basket cells construct invaginating synapses enriched with endocannabinoid signaling proteins in particular cortical and cortex-like amygdaloid regions of mouse brains","volume":"35","author":"Omiya","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.neuron.2015.07.029","article-title":"Dorsal horn circuits for persistent mechanical pain","volume":"87","author":"Peirs","year":"2015","journal-title":"Neuron"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.neuron.2015.02.020","article-title":"Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons","volume":"85","author":"Pelkey","year":"2015","journal-title":"Neuron"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1152\/physrev.00007.2017","article-title":"Hippocampal GABAergic inhibitory interneurons","volume":"97","author":"Pelkey","year":"2017","journal-title":"Physiological Reviews"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"13018","DOI":"10.1523\/JNEUROSCI.1407-14.2014","article-title":"Optogenetic activation of cajal-retzius cells reveals their glutamatergic output and a novel feedforward circuit in the developing mouse Hippocampus","volume":"34","author":"Quattrocolo","year":"2014","journal-title":"Journal of Neuroscience"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1038\/nn.3823","article-title":"Single rodent mesohabenular axons release glutamate and GABA","volume":"17","author":"Root","year":"2014","journal-title":"Nature Neuroscience"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1016\/j.celrep.2018.05.063","article-title":"Selective brain distribution and distinctive synaptic architecture of dual Glutamatergic-GABAergic neurons","volume":"23","author":"Root","year":"2018","journal-title":"Cell Reports"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1007\/s00429-017-1417-z","article-title":"Morphological and physiological properties of CCK\/CB1R-expressing interneurons in the basal amygdala","volume":"222","author":"Rovira-Esteban","year":"2017","journal-title":"Brain Structure and Function"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1042\/BJ20110679","article-title":"Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease","volume":"442","author":"Rush","year":"2012","journal-title":"Biochemical Journal"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1038\/mp.2015.104","article-title":"The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens","volume":"20","author":"Sakae","year":"2015","journal-title":"Molecular Psychiatry"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177069","article-title":"Vesicular glutamate transporters play a role in neuronal differentiation of cultured SVZ-derived neural precursor cells","volume":"12","author":"S\u00e1nchez-Mendoza","year":"2017","journal-title":"PLOS ONE"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"50734","DOI":"10.1074\/jbc.M206738200","article-title":"Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons","volume":"277","author":"Sch\u00e4fer","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1523\/JNEUROSCI.2238-16.2016","article-title":"Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate cotransmission","volume":"37","author":"Sengupta","year":"2017","journal-title":"The Journal of Neuroscience"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1126\/science.1250469","article-title":"Mood regulation\u00a0GABA\/glutamate co-release controls habenula output and is modified by antidepressant treatment","volume":"345","author":"Shabel","year":"2014","journal-title":"Science"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0022-510X(94)90148-1","article-title":"Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats","volume":"121","author":"Sharma","year":"1994","journal-title":"Journal of the Neurological Sciences"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.0953-816X.2003.03091.x","article-title":"GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in Hippocampus and isocortex of the rat","volume":"19","author":"Somogyi","year":"2004","journal-title":"European Journal of Neuroscience"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2174\/156802606777323737","article-title":"Functional significance of co-localization of GABA and glu in nerve terminals: a hypothesis","volume":"6","author":"Somogyi","year":"2006","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-neuro-072116-031204","article-title":"Neurotransmitter switching in the developing and adult brain","volume":"40","author":"Spitzer","year":"2017","journal-title":"Annual Review of Neuroscience"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1002\/cne.23331","article-title":"Vesicular glutamate transporter-3 in the rodent brain: vesicular colocalization with vesicular \u03b3-aminobutyric acid transporter","volume":"521","author":"Stensrud","year":"2013","journal-title":"Journal of Comparative Neurology"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1002\/cne.23811","article-title":"Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate","volume":"523","author":"Stensrud","year":"2015","journal-title":"Journal of Comparative Neurology"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1002\/hipo.22330","article-title":"Anatomically heterogeneous populations of CB1 cannabinoid receptor-expressing interneurons in the CA3 region of the Hippocampus show homogeneous input-output characteristics","volume":"24","author":"Szab\u00f3","year":"2014","journal-title":"Hippocampus"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/35025070","article-title":"Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons","volume":"407","author":"Takamori","year":"2000","journal-title":"Nature"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-22-j0002.2001","article-title":"Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)","volume":"21","author":"Takamori","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/embo-reports\/kvf159","article-title":"Molecular cloning and functional characterization of human vesicular glutamate transporter 3","volume":"3","author":"Takamori","year":"2002","journal-title":"EMBO reports"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","article-title":"Shared and distinct transcriptomic cell types across neocortical Areas","volume":"563","author":"Tasic","year":"2018","journal-title":"Nature"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1749-6632.1969.tb46376.x","article-title":"Pyridoxine deficiency and brain amino acids","volume":"166","author":"Tews","year":"1969","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.biopsych.2004.10.019","article-title":"Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains","volume":"57","author":"Torrey","year":"2005","journal-title":"Biological Psychiatry"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"10948","DOI":"10.1523\/JNEUROSCI.0323-11.2011","article-title":"A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity","volume":"31","author":"Tricoire","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib85","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00113","article-title":"Glutamate cotransmission in cholinergic, GABAergic and monoamine systems: contrasts and commonalities","volume":"12","author":"Trudeau","year":"2018","journal-title":"Frontiers in Neural Circuits"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1126\/science.1178307","article-title":"Fast synaptic subcortical control of hippocampal circuits","volume":"326","author":"Varga","year":"2009","journal-title":"Science"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/mp.2016.17","article-title":"Persistent inhibitory circuit defects and disrupted social behaviour following in utero exogenous cannabinoid exposure","volume":"22","author":"Vargish","year":"2017","journal-title":"Molecular Psychiatry"},{"key":"bib88","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00039","article-title":"Axonal segregation and role of the vesicular glutamate transporter VGLUT3 in serotonin neurons","volume":"10","author":"Voisin","year":"2016","journal-title":"Frontiers in Neuroanatomy"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.celrep.2019.01.014","article-title":"Dorsal raphe dual Serotonin-Glutamate neurons drive reward by establishing excitatory synapses on VTA mesoaccumbens dopamine neurons","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Reports"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/j.celrep.2017.08.017","article-title":"Neto auxiliary subunits regulate interneuron somatodendritic and presynaptic kainate receptors to control network inhibition","volume":"20","author":"Wyeth","year":"2017","journal-title":"Cell Reports"},{"key":"bib91","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13697","article-title":"Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement","volume":"7","author":"Yoo","year":"2016","journal-title":"Nature Communications"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure cell types in the mouse cortex and Hippocampus revealed by single-cell RNA-seq","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"key":"bib93","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/nn.3945","article-title":"Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons","volume":"18","author":"Zhang","year":"2015","journal-title":"Nature Neuroscience"},{"key":"bib94","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2015.00016","article-title":"Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3","volume":"7","author":"Zimmermann","year":"2015","journal-title":"Frontiers in Synaptic Neuroscience"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/51996\/elife-51996-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/51996\/elife-51996-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/51996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:58:32Z","timestamp":1697057912000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/51996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":94,"alternative-id":["10.7554\/eLife.51996"],"URL":"https:\/\/doi.org\/10.7554\/elife.51996","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.51996.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.737368474.793578489","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.51996.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]},"article-number":"e51996"}}