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Despite many computational models of the mechanisms of persistent activity, there is a lack of circuit-level data from the primate to inform the theories. To fill this gap, we simultaneously recorded ensembles of neurons in both LIP and FEF while macaques performed a memory-guided saccade task. A population encoding model revealed strong and symmetric long-timescale recurrent excitation between LIP and FEF. Unexpectedly, LIP exhibited stronger local functional connectivity than FEF, and many neurons in LIP had longer network and intrinsic timescales. The differences in connectivity could be explained by the strength of recurrent dynamics in attractor networks. These findings reveal reciprocal multi-area circuit dynamics in the frontoparietal network during persistent activity and lay the groundwork for quantitative comparisons to theoretical models.<\/jats:p>","DOI":"10.7554\/elife.52460","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T06:00:20Z","timestamp":1588831220000},"source":"Crossref","is-referenced-by-count":70,"title":["Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-8389","authenticated-orcid":true,"given":"Eric","family":"Hart","sequence":"first","affiliation":[{"name":"Center for Perceptual Systems, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-6935","authenticated-orcid":true,"given":"Alexander C","family":"Huk","sequence":"additional","affiliation":[{"name":"Center for Perceptual Systems, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1152\/jn.1989.61.5.900","article-title":"Dynamics of neuronal firing correlation: modulation of \"effective connectivity\"","volume":"61","author":"Aertsen","year":"1989","journal-title":"Journal of Neurophysiology"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688","volume-title":"Categorical Data Analysis","author":"Agresti","year":"2002"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/cercor\/7.3.237","article-title":"Model of global spontaneous activity and local structured activity during delay periods in the cerebral cortex","volume":"7","author":"Amit","year":"1997","journal-title":"Cerebral Cortex"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/BF00248552","article-title":"Neurons of area 7 activated by both visual stimuli and oculomotor behavior","volume":"67","author":"Andersen","year":"1987","journal-title":"Experimental Brain Research"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cne.902960106","article-title":"Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule","volume":"296","author":"Andersen","year":"1990","journal-title":"The Journal of Comparative Neurology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1523\/JNEUROSCI.3334-10.2011","article-title":"Visuotopic organization of macaque posterior parietal cortex: a functional magnetic resonance imaging study","volume":"31","author":"Arcaro","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-psych-120710-100422","article-title":"Theories\u00a0Working Memory:\u00a0models, and controversies","volume":"63","author":"Baddeley","year":"2012","journal-title":"Annual Review of Psychology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1523\/JNEUROSCI.23-13-05446.2003","article-title":"Effects of gaze shifts on maintenance of spatial memory in macaque frontal eye field","volume":"23","author":"Balan","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.conb.2013.10.008","article-title":"Working models of working memory","volume":"25","author":"Barak","year":"2014","journal-title":"Current Opinion in Neurobiology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4568","article-title":"Thalamic projections sustain prefrontal activity during working memory maintenance","volume":"20","author":"Bolkan","year":"2017","journal-title":"Nature Neuroscience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1163\/156856897X00357","article-title":"The psychophysics toolbox","volume":"10","author":"Brainard","year":"1997","journal-title":"Spatial Vision"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1152\/jn.1985.53.3.603","article-title":"Primate frontal eye fields. 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