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Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf protein microarray covering 91% of the proteome, providing first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2239 functionally diverse Pf proteins, showing a wide breadth of humoral response. Antibody-based immune \u2018fingerprints\u2019 in these individuals indicated a strong person-specific immune response at baseline, with little changes in the overall humoral immunoreactivity pattern measured after immunization. The moderate increase in immunogenicity following immunization and the extensive and variable breadth of humoral immune response observed in the volunteers at baseline suggest that pre-exposure reduces vaccine-induced antigen reactivity in unanticipated ways.\n                  <\/jats:p>","DOI":"10.7554\/elife.53080","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T10:00:03Z","timestamp":1594720803000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.53080","source":"Crossref","is-referenced-by-count":23,"title":["Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9762-851X","authenticated-orcid":true,"given":"Flavia","family":"Camponovo","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, 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