{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:07:26Z","timestamp":1790813246236,"version":"4.1.0"},"reference-count":40,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K15733"],"award-info":[{"award-number":["JP16K15733"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25670733"],"award-info":[{"award-number":["JP25670733"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Age-associated sterile inflammation can cause dysregulated choroidal neovascularization (CNV) as age-related macular degeneration (AMD). Intraocular fluid screening of 234 AMD patients identified high levels of IL-4. The purpose of this study was to determine the functional role of IL-4 in CNV formation using murine CNV model. Our results indicate that the IL-4\/IL-4 receptors (IL4Rs) controlled tube formation and global proangiogenic responses of bone marrow cells. CCR2\n                    <jats:sup>+<\/jats:sup>\n                    bone marrow cells were recruited to form very early CNV lesions. IL-4 rapidly induces CCL2, which enhances recruitment of CCR2\n                    <jats:sup>+<\/jats:sup>\n                    bone marrow cells. This in vivo communication, like quorum-sensing, was followed by the induction of IL-4 by the bone marrow cells during the formation of mature CNVs. For CNV development, IL-4 in bone marrow cells are critically required, and IL-4 directly promotes CNV formation mainly by IL-4R. The IL-4\/IL-4R\u03b1 axis contributes to pathological angiogenesis through communications with bone marrow cells leading to retinal degeneration.\n                  <\/jats:p>","DOI":"10.7554\/elife.54257","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T20:00:35Z","timestamp":1588622435000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.54257","source":"Crossref","is-referenced-by-count":29,"title":["Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-9420","authenticated-orcid":true,"given":"Takashi","family":"Baba","sequence":"first","affiliation":[{"name":"Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Division of 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