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However, it remains unclear what long-term changes in neural circuitry result from disruptions in these genes, and how these circuit changes might contribute to abnormal behaviors. To address these questions, we studied behavior and physiology in mice heterozygous for\n                    <jats:italic>Pogz<\/jats:italic>\n                    , a high confidence autism gene.\n                    <jats:italic>Pogz<\/jats:italic>\n                    <jats:sup>+\/-<\/jats:sup>\n                    mice exhibit reduced anxiety-related avoidance in the elevated plus maze (EPM). Theta-frequency communication between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) is known to be necessary for normal avoidance in the EPM. We found deficient theta-frequency synchronization between the vHPC and mPFC in vivo. When we examined vHPC\u2013mPFC communication at higher resolution, vHPC input onto prefrontal GABAergic interneurons was specifically disrupted, whereas input onto pyramidal neurons remained intact. These findings illustrate how the loss of a high confidence autism gene can impair long-range communication by causing inhibitory circuit dysfunction within pathways important for specific behaviors.\n                  <\/jats:p>","DOI":"10.7554\/elife.54835","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T08:00:55Z","timestamp":1604649655000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.54835","source":"Crossref","is-referenced-by-count":42,"title":["Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz"],"prefix":"10.7554","volume":"9","author":[{"given":"Margaret M","family":"Cunniff","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirene","family":"Markenscoff-Papadimitriou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-7667","authenticated-orcid":true,"given":"John LR","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-4186","authenticated-orcid":true,"given":"Vikaas Singh","family":"Sohal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.neuron.2018.09.029","article-title":"Somatostatin interneurons facilitate Hippocampal-Prefrontal synchrony and prefrontal spatial 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