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Overexpression and activation of FOXM1 is frequent in high-grade serous carcinoma (HGSC), the most common and lethal form of human ovarian cancer, and is linked to copy number gains at chromosome 12p13.33. We show that\n                    <jats:italic>FOXM1<\/jats:italic>\n                    is co-amplified and co-expressed with\n                    <jats:italic>RHNO1<\/jats:italic>\n                    , a gene involved in the ATR-Chk1 signaling pathway that functions in the DNA replication stress response. We demonstrate that\n                    <jats:italic>FOXM1<\/jats:italic>\n                    and\n                    <jats:italic>RHNO1<\/jats:italic>\n                    are head-to-head (i.e., bidirectional) genes (BDG) regulated by a bidirectional promoter (BDP) (named F\/R-BDP). FOXM1 and RHNO1 each promote oncogenic phenotypes in HGSC cells, including clonogenic growth, DNA homologous recombination repair, and poly-ADP ribosylase inhibitor resistance. FOXM1 and RHNO1 are one of the first examples of oncogenic BDG, and therapeutic targeting of FOXM1\/RHNO1 BDG is a potential therapeutic approach for ovarian and other cancers.\n                  <\/jats:p>","DOI":"10.7554\/elife.55070","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T08:04:07Z","timestamp":1619165047000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55070","source":"Crossref","is-referenced-by-count":44,"title":["Co-regulation and function of FOXM1\/RHNO1 bidirectional genes in cancer"],"prefix":"10.7554","volume":"10","author":[{"given":"Carter J","family":"Barger","sequence":"first","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chee","sequence":"additional","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Albahrani","sequence":"additional","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Munoz-Trujillo","sequence":"additional","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Boghean","sequence":"additional","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Branick","sequence":"additional","affiliation":[{"name":"Eppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunle","family":"Odunsi","sequence":"additional","affiliation":[{"name":"Departments of Gynecologic Oncology, Immunology, and Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"Penn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Zou","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer 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