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Here we examine the formation of synaptic circuitry under cellular heterotopia in hippocampal CA1, using a mouse model of the human neurodevelopmental disorder Type I Lissencephaly. We identify calbindin-expressing principal cells which are mispositioned under cellular heterotopia. Ectopic calbindin-expressing principal cells develop relatively normal morphological features and stunted intrinsic physiological features. Regarding network development, a connectivity preference for cholecystokinin-expressing interneurons to target calbindin-expressing principal cells is diminished. Moreover, in vitro gamma oscillatory activity is less synchronous across heterotopic bands and mutants are less responsive to pharmacological inhibition of cholecystokinin-containing interneurons. This study will aid not only in our understanding of how cellular networks form but highlight vulnerable cellular circuit motifs that might be generalized across disease states.<\/jats:p>","DOI":"10.7554\/elife.55173","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T08:00:17Z","timestamp":1592553617000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55173","source":"Crossref","is-referenced-by-count":8,"title":["Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-3692","authenticated-orcid":true,"given":"James A","family":"D'Amour","sequence":"first","affiliation":[{"name":"Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"},{"name":"Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Ekins","sequence":"additional","affiliation":[{"name":"Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"},{"name":"Brown University, Department of Neuroscience, Providence, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuti","family":"Ganatra","sequence":"additional","affiliation":[{"name":"Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-0157","authenticated-orcid":true,"given":"Chris J","family":"McBain","sequence":"additional","affiliation":[{"name":"Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"bib1","first-page":"1","article-title":"Time of neuron origin in the hippocampal region an autoradiographic study in the mouse","volume":"2","author":"Angeivine","year":"1965","journal-title":"Experimental Neurology"},{"key":"bib2","first-page":"2319","article-title":"Lissencephaly: a review with a rare case report","volume":"3","author":"Anusha","year":"2014","journal-title":"International Journal of Science and Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1113\/jphysiol.2011.223669","article-title":"Basket cell dichotomy in microcircuit function","volume":"590","author":"Armstrong","year":"2012","journal-title":"The Journal of Physiology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/cne.903600111","article-title":"Dendritic morphology of CA1 pyramidal neurones from the rat Hippocampus: I. branching patterns","volume":"360","author":"Bannister","year":"1995","journal-title":"The Journal of Comparative Neurology"},{"key":"bib5","first-page":"491","article-title":"Factors involved in the establishment of specific interconnections between thalamus and cerebral cortex","author":"Blakemore","year":"1990","unstructured":"Blakemore C, Moln\u00e1r Z. 1990. 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